Overexpression of COX2 indicates poor survival in urothelial bladder cancer

被引：26
作者：
Agrawal, Usha [1 ,2 ]
Kumari, Nitu [1 ,3 ]
Vasudeva, Pawan [4 ]
Mohanty, Nayan K. [5 ]
Saxena, Sunita [1 ]
机构：
[1] Indian Council Med Res, Natl Inst Pathol, New Delhi 110029, India
[2] Symbiosis Int Univ, Fac Hlth & Biomed Sci, Pune 412115, Maharashtra, India
[3] BITS, Pilani, Rajasthan, India
[4] VMMC & Safdarjung Hosp, Dept Urol, New Delhi 110029, India
[5] Saket City Hosp, Press Enclave Rd, New Delhi 110017, India
来源：
ANNALS OF DIAGNOSTIC PATHOLOGY | 2018年 / 34卷
关键词：
COX2; Urothelial bladder cancer; CYCLOOXYGENASE-2; COX-2; STROMA COMPARTMENTS; TUMOR; EXPRESSION; RECURRENCE; INFLAMMATION; PROGRESSION; INHIBITORS; NEOPLASM; CELLS;
D O I：
10.1016/j.anndiagpath.2018.01.008
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Background: COX2 is a cyclo-oxygenase enzyme expressed in the tumor cells, inflammatory cells, stromal and non-epithelial cells. The study was conducted to evaluate the expression of COX2 in Urothelial carcinoma and find the association with progression and recurrence. Methods: The expression of COX2 was evaluated by real-time PCR and immunohistochemistry. Results: Gene expression of COX2 was found to be upregulated > 28-fold in urothelial cancer compared to adjacent normal bladder mucosa. Inflammatory cell expression of COX2 was found in 92% cases whereas only 37% cases showed COX2 overexpression in tumor cells. Tumor cell COX2 overexpression was significantly associated with invasion and recurrence. Conclusion: COX2 expression is a marker of invasion, recurrence and poor survival and may have a role in predicting the cases which will benefit from additional treatment with COX2 inhibitors in urothelial carcinoma.
引用
收藏
页码：50 / 55
页数：6
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