Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes

被引：195

作者：

Gans, Melissa D. ^{[1
]}

Gavrilova, Tatyana ^{[1
]}

机构：

[1] Montefiore Med Ctr, Div Allergy & Immunol, 1525 Blondell Ave, Bronx, NY 10461 USA

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2020年 / 36卷

关键词：

Asthma; Immunology; Pathophysiology; Phenotypes; Review; Biomarkers; EXHALED NITRIC-OXIDE; INHALED CORTICOSTEROIDS; ALLERGIC-ASTHMA; BRONCHIAL THERMOPLASTY; LUNG-FUNCTION; VITAMIN-D; SAFETY; MANAGEMENT; EFFICACY; IGE;

D O I：

10.1016/j.prrv.2019.08.002

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Asthma is a common disease in paediatrics and adults with a significant morbidity, mortality, and financial burden worldwide. Asthma is now recognized as a heterogeneous disease and emerging clinical and laboratory research has elucidated understanding of asthma's underlying immunology. The future of asthma is classifying asthma by endotype through connecting discernible characteristics with immunological mechanisms. This comprehensive review of the immunology of asthma details the currently known pathophysiology and clinical practice biomarkers in addition to forefront biologic and targeted therapies for all of the asthma endotypes. By understanding the immunology of asthma, practitioners will be able to diagnose patients by asthma endotype and provide personalized, biomarker-driven treatments to effectively control patients' asthma. (c) 2019 Elsevier Ltd. All rights reserved.

引用

页码：118 / 127

页数：10

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