A double alkylation - ring closing metathesis approach to spiroimines

被引：34
作者：
Brimble, MA [1 ]
Trzoss, M [1 ]
机构：
[1] Univ Auckland, Dept Chem, Auckland 1, New Zealand
来源：
TETRAHEDRON | 2004年 / 60卷 / 26期
关键词：
gymnodimi; spirolactams; beta-trimethylsilylethoxycarbonyl (TEOC);
D O I：
10.1016/j.tet.2004.04.059
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
As part of a programme directed towards the synthesis of the marine toxins, the spirolides and gymnodimine, a convenient synthesis of the key bicyclic spiroimine ring systems has been developed. The method involves double alkylation of a simple lactam, Grubbs ring closing metathesis of the resultant dialkylated lactam then reduction of the lactam to an imine. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：5613 / 5622
页数：10
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