SICOR: Subgraph Isomorphism Comparison of RNA Secondary Structures

被引：1
作者：
Schmidt, Michael [1 ]
Hamacher, Kay [2 ]
Reinhardt, Felix [1 ]
Lotz, Thea S. [3 ]
Groher, Florian [3 ]
Suess, Beatrix [3 ]
Jager, Sven [3 ]
机构：
[1] Tech Univ Darmstadt, Dept Phys, D-64289 Darmstadt, Germany
[2] Tech Univ Darmstadt, Dept Phys, Dept Comp Sci, Dept Biol, D-64289 Darmstadt, Germany
[3] Tech Univ Darmstadt, Dept Biol, D-64289 Darmstadt, Germany
来源：
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS | 2020年 / 17卷 / 06期
关键词：
RNA; Transmission line matrix methods; Probabilistic logic; Measurement; Libraries; Protocols; Forestry; RNA structure comparison; subgraph isomorphism; SELEX; aptamers; SEQUENCE; IDENTIFICATION; PREDICTION; SELECTION;
D O I：
10.1109/TCBB.2019.2926711
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA aptamer selection during SELEX experiments builds on secondary structural diversity. Advanced structural comparison methods can focus this diversity. We develop SICOR, which uses probabilistic subgraph isomorphisms for graph distances between RNA secondary structure graphs. SICOR outperforms other comparison methods and is applicable to many structural comparisons in experimental design.
引用
收藏
页码：2189 / 2195
页数：7
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