Effect of Atorvastatin on the expression of CD40 ligand and P-selectin on platelets in patients with hypercholesterolemia

被引：31

作者：

Hwang, YS

Tsai, WC

Lu, YH

Lin, CC

Chen, YF

机构：

[1] Kaohsiung Med Univ, Div Cardiol, Dept Internal Med, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Div Immunol, Dept Internal Med, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Div Cardiovasc Surg, Dept Surg, Kaohsiung 807, Taiwan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2004年 / 94卷 / 03期

关键词：

D O I：

10.1016/j.amjcard.2004.04.037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of atorvastatin on levels of the CD40 ligand (CD40L or CD154) and P-selectin on platelets were investigated in patients with hypercholesterolemia. The major finding was that short-term atorvastatin treatment (8 weeks) in a group of hypercholesterolemic patients resulted in significant suppression of CD40L and P-selectin expression. Moreover, there was a significant correlation between the magnitude of CD40L downregulation and that of very low-density lipoprotein cholesterol, the ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol, and triglycerides. In hypercholesterolemic patients, in addition to its effects on decreasing cholesterol, atorvastatin can intervene in the interaction of CD40-CD40L and the expression of P-selectin on platelets. Thus, interference of CD40-CD40L can be recognized as an integral part of the anti-inflammatory activity of atorvastatin in hypercholesterolemia. (C) 2004 by Excerpta Medica, Inc.

引用

页码：364 / 366

页数：3

共 4 条

[1]

DAVINGTON J, 2001, LIPID VASCULAR DIS C, P201

[2] Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia [J].

Garlichs, CD ;

John, S ;

Schmeisser, A ;

Eskafi, S ;

Stumpf, C ;

Karl, M ;

Goppelt-Struebe, M ;

Schmieder, R ;

Daniel, WG .

CIRCULATION, 2001, 104 (20) :2395-2400

[3] Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors: Comparison with other human cell types [J].

NegreAminou, P ;

vanVliet, AK ;

vanErck, M ;

vanThiel, GCF ;

vanLeeuwen, REW ;

Cohen, LH .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1997, 1345 (03) :259-268

[4] Inhibition of proinflammatory cytokine production by pravastatin [J].

Rosenson, RS ;

Tangney, CC ;

Casey, LC .

LANCET, 1999, 353 (9157) :983-984

← 1 →