Cardioprotective Effects of Lignanoid against Doxorubicin-Induced Oxidative Stress in Rat

被引：0

作者：

Wang, Yanchun ^{[1
]}

Ren, Kuang ^{[1
]}

Meng, Lin ^{[1
]}

Fan, Hongyan ^{[1
]}

Shen, Nan ^{[2
]}

机构：

[1] Jilin Med Coll, Sch Basic Med, Jilin 132013, Jilin, Peoples R China

[2] Jilin Med Coll, Expt Ctr, Dept Funct Expt Sci, Jilin 132013, Jilin, Peoples R China

来源：

APPLIED MATERIALS AND TECHNOLOGIES FOR MODERN MANUFACTURING, PTS 1-4 | 2013年 / 423-426卷

关键词：

lignanoid; doxorubicin; lipid peroxidation; CARDIOTOXICITY;

D O I：

10.4028/www.scientific.net/AMM.423-426.382

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This study was aimed to investigate the protective effect of lignanoid against doxorubicin-induced cardiotoxicity in rats. Doxorubicin were administered at the dosage of 5 mg/kg once a week, ip for a period of 5 consecutive weeks. Lignanoid were administered at the dosages of 25, 50 and 100mg/kg, po by gavage for 7 consecutive days in a week for 5 weeks. Lignanoid at the doses of 50 and 100 mg/kg significantly reduced CK-MB, NO and LDH and increased GST levels in the doxorubicin-treated group. Thus, lignanoid ameliorated doxorubicin-induced cardiotoxicity by reducing oxidative stress, abnormal cellular morphology in rat. This study indicates the protective effect of lignanoid against doxorubicin-induced cardiotoxicity.

引用

页码：382 / +

页数：2

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