U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene

被引：15

作者：

Kenmochi, N

Higa, S

Yoshihama, M

Tanaka, T

机构：

[1] Department of Biochemistry, School of Medicine, University of the Ryukyus, Okinawa 903-01, 207 Uehara, Nishihara

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 228卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.1668

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the mapping and sequencing of human ribosomal protein genes, we have found that U14 small nucleolar RNAs (snoRNAs) are encoded in introns of the ribosomal protein S13 gene. PCR cloning and sequencing have been employed to obtain the intron-containing (functional) human S13 gene and to eliminate a number of the processed pseudogenes. The S13 gene consists of six exons and five introns and spans a genomic region of 3.3 kb. U14 snoRNA genes are positioned in introns 3 and 5 of the S13 gene. A sequence comparison of the U14 genes in human and Xenopus laevis revealed that the regions involved in binding to 18S rRNA and the consensus (boxes C and D) of sequences for snoRNAs are highly conserved among the genes in the two species. (C) 1996 Academic Press, Inc.

引用

页码：371 / 374

页数：4

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