Inflammation and NF-κB in Alzheimer's Disease and Diabetes

被引：160

作者：

Granic, Ivica ^{[1
]}

Dolga, Amalia M. ^{[2
]}

Nijholt, Ingrid M. ^{[1
]}

van Dijk, Gertjan ^{[3
]}

Eisel, Ulrich L. M. ^{[1
]}

机构：

[1] Univ Groningen, Dept Mol Neurobiol, NL-9750 AA Haren, Netherlands

[2] Univ Marburg, Dept Pharmacol & Toxicol, D-35032 Marburg, Germany

[3] Univ Groningen, Dept Neuroendocrinol, NL-9750 AA Haren, Netherlands

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2009年 / 16卷 / 04期

关键词：

Alzheimer's disease; inflammation; insulin; insulin-degrading enzyme; nuclear factor-kappa B; receptor for advanced glycation endproducts (RAGE); tumor necrosis factor; type 2 diabetes mellitus; NECROSIS-FACTOR-ALPHA; AMYLOID-BETA-PEPTIDE; INDUCED INSULIN-RESISTANCE; GLYCATION END-PRODUCTS; NITRIC-OXIDE SYNTHASE; TRANSCRIPTION FACTOR; IN-VIVO; SIGNALING PATHWAYS; DEGRADING ENZYME; LIPOIC ACID;

D O I：

10.3233/JAD-2009-0976

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inflammatory processes are a hallmark of many chronic diseases including Alzheimer's disease and diabetes mellitus. Fairly recent statistical evidence indicating that type 2 diabetes increases the risk of developing Alzheimer's disease has led to investigations of the potential common processes that could explain this relation. Here, we review the literature on how inflammation and the inducible nuclear factor NF-kappa B might be involved in both diabetes mellitus and Alzheimer's disease and whether these factors can link both diseases.

引用

页码：809 / 821

页数：13

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