Synthesis and evaluation of in vitro antimicrobial activity of novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles

被引：9

作者：

Girish, V. ^{[1
]}

Khanum, Noor Fatima ^{[2
]}

Gurupadaswamy, H. D. ^{[1
]}

Khanum, Shaukath Ara ^{[1
]}

机构：

[1] Univ Mysore, Dept Chem, Yuvarajas Coll, Mysore 570005, Karnataka, India

[2] Maharanis Sci Coll, Dept Food Sci & Nutr, Mysore 570006, Karnataka, India

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2014年 / 40卷 / 03期

关键词：

benzophenones; 1,3,4-oxadiazoles; antimicrobial activity; MIC; ANTIFUNGAL ACTIVITY; ANTIBACTERIAL; RESISTANCE; AGENTS; PLANT;

D O I：

10.1134/S1068162014030066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthetic pathway of the ten novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles as new potential antimicrobial agents is illustrated. Intramolecular cyclization of 2-(2-aroylaryloxy) aceto hydrazides to 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles was achieved with triethyl orthoformate in good yields. The compounds were characterized by IR, H-1 NMR, mass spectra and by means of CHN analysis. The target compounds were tested for their in vitro antimicrobial activity against representative strains by disc diffusion method and micro dilution methods. Several compounds showed antimicrobial activity comparable with or higher than the standard drugs.

引用

页码：330 / 335

页数：6

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