Synthesis and evaluation of in vitro antimicrobial activity of novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles

被引：9

作者：

Girish, V. ^{[1
]}

Khanum, Noor Fatima ^{[2
]}

Gurupadaswamy, H. D. ^{[1
]}

Khanum, Shaukath Ara ^{[1
]}

机构：

[1] Univ Mysore, Dept Chem, Yuvarajas Coll, Mysore 570005, Karnataka, India

[2] Maharanis Sci Coll, Dept Food Sci & Nutr, Mysore 570006, Karnataka, India

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2014年 / 40卷 / 03期

关键词：

benzophenones; 1,3,4-oxadiazoles; antimicrobial activity; MIC; ANTIFUNGAL ACTIVITY; ANTIBACTERIAL; RESISTANCE; AGENTS; PLANT;

D O I：

10.1134/S1068162014030066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthetic pathway of the ten novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles as new potential antimicrobial agents is illustrated. Intramolecular cyclization of 2-(2-aroylaryloxy) aceto hydrazides to 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles was achieved with triethyl orthoformate in good yields. The compounds were characterized by IR, H-1 NMR, mass spectra and by means of CHN analysis. The target compounds were tested for their in vitro antimicrobial activity against representative strains by disc diffusion method and micro dilution methods. Several compounds showed antimicrobial activity comparable with or higher than the standard drugs.

引用

页码：330 / 335

页数：6

共 50 条

[1] Synthesis and evaluation of in vitro antimicrobial activity of novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles
V. Girish
Noor Fatima Khanum
H. D. Gurupadaswamy
Shaukath Ara Khanum
Russian Journal of Bioorganic Chemistry, 2014, 40 : 330 - 335
[2] Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety
Naveena, Channamata Shankara
Boja, Poojary
Kumari, Nalilu Sucheta
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (11) : 4708 - 4719
[3] Synthesis and Antimicrobial Assessment of Some New 2-(Thiazol-5-yl)-1,3,4-oxadiazoles
Araniciu, Catalin
Oniga, Smaranda Dafina
Stoica, Cristina Ioana
Chifiriuc, Mariana Carmen
Popa, Marcela
Vlase, Laurian
Palage, Mariana
Oniga, Ovidiu
REVISTA DE CHIMIE, 2019, 70 (06): : 1996 - 1999
[4] SYNTHESIS AND CHARACTERIZATION OF NEW 2-(2-THIENYL)-5-ARYL-1,3,4-OXADIAZOLES
Badiceanu, Carmellina Daniela
Nuta, Diana Camelia
Missir, Alexandru-Vasile
Hrubaru, Madalina
Limban, Carmen
FARMACIA, 2018, 66 (03) : 553 - 557
[5] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF PYRAZOLYL 1,3,4-OXADIAZOLES
Padmavathi, Venkatapuram
Reddy, Gali Sudhakar
Reddy, Guda Dinneswara
Payani, Thalari
SYNTHETIC COMMUNICATIONS, 2010, 40 (04) : 482 - 493
[6] Synthesis and biological evaluation of novel 2-(substituted isoxazol-4-yl)-5-arylamino-1,3,4-oxadiazoles
Liu, Feng
Wang, Meiyan
Teng, Xinhuan
Zhang, Peizhi
Jiang, Lin
RESEARCH ON CHEMICAL INTERMEDIATES, 2014, 40 (04) : 1575 - 1581
[7] Synthesis and biological evaluation of novel 2-(substituted isoxazol-4-yl)-5-arylamino-1,3,4-oxadiazoles
Feng Liu
Meiyan Wang
Xinhuan Teng
Peizhi Zhang
Lin Jiang
Research on Chemical Intermediates, 2014, 40 : 1575 - 1581
[8] Synthesis, characterization, and antimicrobial activity of some novel thiazole clubbed 1,3,4-oxadiazoles
Desai, N. C.
Bhatt, Nayan
Somani, Hardik
MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (01) : 258 - 266
[9] Design, synthesis and biological evaluation of novel substituted indazole-1,2,3-triazolyl-1,3,4-oxadiazoles: Antimicrobial activity evaluation and docking study
Dunga, Ananda Kumar
Allaka, Tejeswara Rao
Kethavarapu, Yugandhar
Nechipadappu, Sunil Kumar
Pothana, Pradeep
Ravada, Kishore
Kashanna, Jajula
Kishore, Pilli V. V. N.
RESULTS IN CHEMISTRY, 2022, 4
[10] Novel pyrazole integrated 1,3,4-oxadiazoles: Synthesis, characterization and antimicrobial evaluation
Ningaiah, Srikantamurthy
Bhadraiah, Umesha K.
Doddaramappa, Shridevi D.
Keshavamurthy, Shubakara
Javarasetty, Chethan
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (01) : 245 - 248

← 1 2 3 4 5 →