Application of bioactive metal ions in the treatment of bone defects

被引：53
作者：
Li, Shaorong [1 ]
Cui, Yutao [1 ]
Liu, He [1 ]
Tian, Yuhang [1 ]
Wang, Gan [1 ]
Fan, Yi [1 ]
Wang, Jingwei [1 ]
Wu, Dankai [1 ]
Wang, Yanbing [1 ]
机构：
[1] Jilin Univ, Orthopaed Med Ctr, Hosp 2, Changchun 130041, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2022年 / 10卷 / 45期
基金：
中国国家自然科学基金;
关键词：
IN-VIVO EVALUATION; ANTIBACTERIAL ACTIVITY; GLASS SCAFFOLDS; TRICALCIUM PHOSPHATE; SUBSTITUTED HYDROXYAPATITE; BACTERICIDAL ACTIVITY; SILVER-NANOPARTICLES; COMPOSITE SCAFFOLD; GROWTH-FACTOR; SR ALLOY;
D O I：
10.1039/d2tb01684b
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The treatment of bone defects is an important problem in clinical practice. The rapid development of bone tissue engineering (BTE) may provide a new method for bone defect treatment. Metal ions have been widely studied in BTE and demonstrated a significant effect in promoting bone tissue growth. Different metal ions can be used to treat bone defects according to specific conditions, including promoting osteogenic activity, inhibiting osteoclast activity, promoting vascular growth, and exerting certain antibacterial effects. Multiple studies have confirmed that metal ions-modified composite scaffolds can effectively promote bone defect healing. By studying current extensive research on metal ions in the treatment of bone defects, this paper reviews the mechanism of metal ions in promoting bone tissue growth, analyzes the loading mode of metal ions, and lists some specific applications of metal ions in different types of bone defects. Finally, this paper summarizes the advantages and disadvantages of metal ions and analyzes the future research trend of metal ions in BTE. This article can provide some new strategies and methods for future research and applications of metal ions in the treatment of bone defects.
引用
收藏
页码：9369 / 9388
页数：20
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