Synthesis and antibacterial evaluation of 3,3'-diindolylmethane derivatives

被引：37

作者：

Roy, Sutapa ^{[1
]}

Gajbhiye, Rahul ^{[2
]}

Mandal, Madhumita ^{[2
]}

Pal, Churala ^{[2
]}

Meyyapan, Arumugam ^{[1
]}

Mukherjee, Joydeep ^{[1
]}

Jaisankar, Parasuraman ^{[2
]}

机构：

[1] Jadavpur Univ, Sch Environm Studies, Kolkata 700032, India

[2] CSIR Indian Inst Chem Biol, Dept Chem, Kolkata 700032, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2014年 / 23卷 / 03期

关键词：

Diindolylmethane; Antibacterial activity; MIC; Hemolytic activity; Cytotoxicity; VITRO ANTIMICROBIAL ACTIVITY; ONE-POT SYNTHESIS;

D O I：

10.1007/s00044-013-0737-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Various 3,3'-diindolylmethane (DIM) derivatives were synthesized and the antibacterial activity of these compounds were tested against ten bacterial strains and their minimum inhibitory concentration (MIC) values were determined. The MIC values of derivatives 3a-d and 5a-e were ranging from 125 to 500 mu g/mL. Among these derivatives, 2-(di(1H-indol-3-yl)methyl)phenol (5a) and 3-((1H-indol-3-yl)(pyridin-3-yl)methyl)-1H-indole (5d) exhibited potent activity, showing MIC values 6.5-62.5 mu g/mL against Gram positive and Gram negative bacteria. Hemolytic assay of these active DIM derivatives did not show considerable toxic effect on the normal human erythrocytes.

引用

页码：1371 / 1377

页数：7

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