CD8+ Tregs kill pathogenic cells to avert autoimmunity

被引：3

作者：

Hu, Dan ^{[1
,2
]}

Murugaiyan, Gopal ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

来源：

TRENDS IN IMMUNOLOGY | 2022年 / 43卷 / 06期

关键词：

REGULATORY T-CELLS; KIR;

D O I：

10.1016/j.it.2022.04.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mouse Ly49(+)CD8(+) regulatory T cells (Tregs) can subdue autoreactive CD4(+) T cells to suppress autoimmunity. Recently, Li et al. demonstrated that killer-cell immunoglobulin-like receptor (KIR)+CD8(+) T cells are the human equivalent of Ly49(+)CD8(+) regulatory T cells and kill pathogenic CD4(+) T cells, which can be increased in certain human autoimmune diseases and viral infections.

引用

页码：415 / 416

页数：2

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