Traditional Chinese Medicine Tanreqing Targets Both Cell Division and Virulence in Staphylococcus aureus

被引：12
|
作者：
Yang, Weifeng [1 ]
Cui, Kaiyu [1 ]
Tong, Qian [2 ]
Ma, Shuhua [1 ]
Sun, Yanan [1 ]
He, Gaiying [1 ]
Li, Dongying [1 ]
Lin, Longfei [3 ]
Blazekovic, Biljana [4 ]
Chevalier, Sylvie [5 ]
Wang, Yuanhong [6 ]
Wei, Qing [7 ]
Wang, Yi [1 ]
机构：
[1] China Acad Chinese Med Sci, Expt Res Ctr, Beijing, Peoples R China
[2] Hubei Univ Technol, Sch Biol Engn & Food Sci, Wuhan, Peoples R China
[3] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China
[4] Univ Zagreb, Fac Pharm & Biochem, Dept Pharmacognosy, Zagreb, Croatia
[5] Univ Rouen Normandy, Normandy Univ, Lab Microbiol Signals & Microenvironm, Evreux, France
[6] Tianjin Agr Univ, Coll Hort & Landscape, Tianjin, Peoples R China
[7] Nanchang Inst Technol, Nanchang, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2022年 / 12卷
关键词：
Tanreqing; cell division; virulence; inhibition; Staphylococcus aureus; FTSZ; IDENTIFICATION; INHIBITORS; MGRA; REGULATOR; MECHANISM; PATHWAYS; INSIGHTS; SEPTUM;
D O I：
10.3389/fcimb.2022.884045
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Staphylococcus aureus has been recognized as an important human pathogen and poses a serious health threat worldwide. With the advent of antibiotic resistance, such as the increased number of methicillin-resistant Staphylococcus aureus (MRSA), there is an urgent need to develop new therapeutical agents. In this study, Chinese traditional medicine Tanreqing (TRQ) has been used as an alternative treating agent against MRSA and we aim to unravel the mode of action of TRQ underlying MRSA inhibition. TRQ treatment affected numerous gene expression as revealed by RNA-seq analysis. Meanwhile, TRQ targeted cell division to inhibit cell growth as shown by illumination microscopy. Besides, we confirmed that TRQ downregulates the expression of virulence factors such as hemolysin and autolysin. Finally, we used a murine model to demonstrate that TRQ efficiently reduces bacterial virulence. Altogether, we have proved TRQ formula to be an effective agent against S. aureus infections.
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页数：11
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