A comparison of the in vitro antimicrobial activity of liposomes containing meropenem and gentamicin

被引：41
作者：
Drulis-Kawa, Zuzanna
Gubernator, Jerzy
Dorotkiewicz-Jach, Agata
Doroszkiewicz, Wlodzimierz
Kozubek, Arkadiusz
机构：
[1] Univ Wroclaw, Inst Genet & Microbiol, PL-51148 Wroclaw, Poland
[2] Univ Wroclaw, Inst Biochem & Mol Biol, PL-51148 Wroclaw, Poland
[3] Lower Silesian Ctr Paediat Wroclaw, PL-51147 Wroclaw, Poland
[4] Acad Ctr Biotechnol Supramol Lipid Aggregates, PL-51148 Wroclaw, Poland
来源：
CELLULAR & MOLECULAR BIOLOGY LETTERS | 2006年 / 11卷 / 03期
关键词：
liposomes; meropenem; gentamicin; bacteria;
D O I：
10.2478/s11658-006-0030-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antimicrobial activity of eight cationic, two neutral and three anionic liposome compositions containing meropenem and gentamicin was tested in vitro in broth and serum medium. The cationic formulations showed better antibacterial efficacy against both Gram-positive and Gram-negative bacteria than the anionic and neutral ones, regardless of the encapsulated drug. The most effective formulations were the cationic PC/DOPE/DOTAP 3:43 and PC/Chol/DOTAP 3:43, as the MICs, with meropenem were 2 to 4 times lower than those of the free drug.
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收藏
页码：360 / 375
页数：16
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