The design and synthesis of simple molecular tethers for binding biomembranes to a gold surface

被引：76

作者：

Boden, N ^{[1
]}

Bushby, RJ ^{[1
]}

Clarkson, S ^{[1
]}

Evans, SD ^{[1
]}

Knowles, PF ^{[1
]}

Marsh, A ^{[1
]}

机构：

[1] UNIV LEEDS,CTR SELF ORGANISING MOL SYST,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 31期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4020(97)00698-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Molecular tethers have been synthesised for fixing biomembranes to a gold surface. These are comprised of a thiol at one end to bind to the gold, a polyethylenoxy chain of defined length (two, six or twelve ethylenoxy units) in the middle and a cholesteryl residue at the other end to insert into the biomembrane. (C) 1997 Elsevier Science Ltd.

引用

页码：10939 / 10952

页数：14

共 19 条

[1] PHASE-TRANSFER-CATALYZED SYNTHESIS OF OLIGOETHYLENE GLYCOLS AND DERIVATIVES [J].

BARTSCH, RA ;

CASON, CV ;

CZECH, BP .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (04) :857-860

[2] SELF-ASSEMBLY OF COVALENTLY ANCHORED PHOSPHOLIPID SUPPORTED MEMBRANES BY USE OF DODA-SUC-NHS-LIPIDS [J].

BRINK, G ;

SCHMITT, L ;

TAMPE, R ;

SACKMANN, E .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1994, 1196 (02) :227-230

[3]

BUSHBY RJ, UNPUB

[4] APPLICATION OF THE OKAHARA CYCLIZATION TO THE PREPARATION OF CROWN ETHERS WITH AROMATIC UNITS [J].

CZECH, B ;

CZECH, A ;

BARTSCH, RA .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1984, 21 (02) :341-343

[5] BIOLOGICALLY ADDRESSABLE MONOLAYER STRUCTURES FORMED BY TEMPLATES OF SULFUR-BEARING MOLECULES [J].

DUSCHL, C ;

LILEY, M ;

CORRADIN, G ;

VOGEL, H .

BIOPHYSICAL JOURNAL, 1994, 67 (03) :1229-1237

[6]

DUSCHL C, 1994, ANGEW CHEM INT EDIT, V33, P1274, DOI 10.1002/anie.199412741

[7]

Fordyce R., 1939, J AM CHEM SOC, V61, P1905

[8]

GEHRHARDT H, 1987, POLYM BULL, V18, P487

[9]

GREENE TW, 1991, PROTECTIVE GROUPS OR

[10] COVALENT ATTACHMENT OF FUNCTIONALIZED LIPID BILAYERS TO PLANAR WAVE-GUIDES FOR MEASURING PROTEIN-BINDING TO BIOMIMETIC MEMBRANES [J].

HEYSEL, S ;

VOGEL, H ;

SANGER, M ;

SIGRIST, H .

PROTEIN SCIENCE, 1995, 4 (12) :2532-2544

← 1 2 →