The HEALing (Helping to End Addiction Long-termSM) Communities Study: Protocol for a cluster randomized trial at the community level to reduce opioid overdose deaths through implementation of an integrated set of evidence-based practices

被引：102

作者：

Walsh, Sharon L. ^{[1
]}

El-Bassel, Nabila ^{[2
]}

Jackson, Rebecca D. ^{[3
]}

Samet, Jeffrey H. ^{[4
,6
]}

Aggarwal, Maneesha ^{[2
]}

Aldridge, Arnie P. ^{[5
]}

Baker, Trevor ^{[6
]}

Barbosa, Carolina ^{[5
]}

Barocas, Joshua A. ^{[4
,6
]}

Battaglia, Tracy A. ^{[4
,6
]}

Beers, Donna ^{[6
]}

Bernson, Dana ^{[7
]}

Bowers-Sword, Rachel ^{[6
]}

Bridden, Carly ^{[6
]}

Brown, Jennifer L. ^{[8
]}

Bush, Heather M. ^{[1
]}

Bush, Joshua L. ^{[1
]}

Button, Amy ^{[9
]}

Campbell, Aimee N. C. ^{[2
]}

Cerda, Magdalena ^{[10
]}

Cheng, Debbie M. ^{[4
]}

Chhatwal, Jag ^{[11
]}

Clarke, Thomas ^{[12
]}

Conway, Kevin P. ^{[5
]}

Crable, Erika L. ^{[4
]}

Czajkowski, Andrea ^{[13
]}

David, James L. ^{[2
]}

Drainoni, Mari-Lynn ^{[4
]}

Fanucchi, Laura C. ^{[1
]}

Feaster, Daniel J. ^{[14
]}

Fernandez, Soledad ^{[3
]}

Freedman, Darcy ^{[15
]}

Freisthler, Bridget ^{[3
]}

Gilbert, Louisa ^{[2
]}

Glasgow, LaShawn M. ^{[5
]}

Goddard-Eckrich, Dawn ^{[2
]}

Gutnick, Damara ^{[9
]}

Harlow, Kristin ^{[3
]}

Helme, Donald W. ^{[1
]}

Huang, Terry ^{[16
]}

Huerta, Timothy R. ^{[3
]}

Hunt, Timothy ^{[2
]}

Hyder, Ayaz ^{[3
]}

Kerner, Robin ^{[2
]}

Keyes, Katherine ^{[2
]}

Knott, Charles E. ^{[5
]}

Knudsen, Hannah K. ^{[1
]}

Konstan, Michael ^{[15
]}

Larochelle, Marc R. ^{[4
,6
]}

Lefebvre, R. Craig ^{[5
]}

机构：

[1] Univ Kentucky, Lexington, KY 40508 USA

[2] Columbia Univ, New York, NY USA

[3] Ohio State Univ, Columbus, OH 43210 USA

[4] Boston Univ, Boston, MA 02215 USA

[5] RTI Int, Res Triangle Pk, NC USA

[6] Boston Med Ctr, Boston, MA USA

[7] Massachusettes Dept Publ Hlth, Boston, MA USA

[8] Univ Cincinnati, Cincinnati, OH USA

[9] Montefiore, New Rochelle, NY USA

[10] NYU, New York, NY USA

[11] Massachusetts Gen Hosp, Boston, MA 02114 USA

[12] Subst Abuse & Mental Hlth Serv Assoc, Rockville, MD USA

[13] NIDA, Bethesda, MD 20892 USA

[14] Miami Univ, Miami, FL USA

[15] Case Western Univ, Cleveland, OH USA

[16] CUNY, New York, NY 10021 USA

[17] Ohio Univ, Athens, OH 45701 USA

[18] Cornell Univ, New York, NY 10021 USA

[19] Univ North Texas, Hlth Sci Ctr, Ft Worth, TX USA

来源：

DRUG AND ALCOHOL DEPENDENCE | 2020年 / 217卷

基金：

美国国家卫生研究院;

关键词：

Y Opioid use disorder (OUD); Overdose; Community engagement; Medications for opioid use disorder (MOUD); Naloxone; Opioid prescribing; Helping to End Addiction Long-term; HEALing Communities Study; HEALTH COMMUNICATION CAMPAIGNS; USE DISORDER; UNITED-STATES; SUBSTANCE USE; INNOVATIONS; STIGMA; BUPRENORPHINE; ESTIMATOR; INFERENCE; DESIGN;

D O I：

10.1016/j.drugalcdep.2020.108335

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Background: Opioid overdose deaths remain high in the U.S. Despite having effective interventions to prevent overdose deaths, there are numerous barriers that impede their adoption. The primary aim of the HEALing Communities Study (HCS) is to determine the impact of an intervention consisting of community-engaged, data-driven selection, and implementation of an integrated set of evidence-based practices (EBPs) on reducing opioid overdose deaths. Methods: The HCS is a four year multi-site, parallel-group, cluster randomized wait-list controlled trial. Communities (n = 67) in Kentucky, Massachusetts, New York and Ohio are randomized to active intervention (Wave 1), which starts the intervention in Year 1 or the wait-list control (Wave 2), which starts the intervention in Year 3. The HCS will test a conceptually driven framework to assist communities in selecting and adopting EBPs with three components: 1) a community engagement strategy with local coalitions to guide and implement the intervention; 2) a compendium of EBPs coupled with technical assistance; and 3) a series of communication campaigns to increase awareness and demand for EBPs and reduce stigma. An implementation science framework guides the intervention and allows for examination of the multilevel contexts that promote or impede adoption and expansion of EBPs. The primary outcome, number of opioid overdose deaths, will be compared between Wave 1 and Wave 2 communities during Year 2 of the intervention for Wave 1. Numerous secondary outcomes will be examined. Discussion: The HCS is the largest community-based implementation study in the field of addiction with an ambitious goal of significantly reducing fatal opioid overdoses.

引用

页数：11

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