Sexual dysfunction and psychotropic medications

被引:39
作者
Stimmel, Glen L.
Gutierrez, Mary A.
机构
[1] Univ So Calif, Sch Pharm, Los Angeles, CA 90089 USA
[2] Eli Lilly & Co, Indianapolis, IN 46285 USA
关键词
D O I
10.1017/S1092852900026730
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Psychotropic drugs are often associated with sexual dysfunction. The frequency of antidepressant-associated sexual dysfunction is greatly underestimated in clinical trials that rely on patient self-report of these adverse events. Direct inquiry reveals that delayed orgasm/ejaculation occurs in >= 50% and anorgasmia in at least one third of patients given selective serotonin reuptake inhibitors. Antidepressant-induced sexual dysfunction can be successfully managed. A different antidepressant without significant sexual effects, such as bupropion or mirtazapine, can often be substituted. Other strategies involve drug holidays or adjunctive therapy with drugs such as sildenafil. Dopamine antagonist antipsychotic drugs are most commonly associated with decreased libido. The newer atypical antipsychotics, with less effect on dopamine, are less commonly associated with sexual dysfunction. Sexual dysfunction is commonly reported with seizure disorders, and many anticonvulsant drugs affect levels of sex hormones. Because sexual dysfunction can be related to many factors, care must be taken to establish the patient's baseline sexual functioning before the initiation of psychotropic drug therapy and to rule out other etiologies before drugs are implicated as causative.
引用
收藏
页码:24 / 30
页数:7
相关论文
共 50 条
[41]   Breastfeeding and psychotropic medications [J].
Worsley, Roisin ;
Gilbert, Heather ;
Gavrilidis, Emorfia ;
Naughton, Brooke ;
Kulkarni, Jayashri .
LANCET, 2013, 381 (9870) :905-905
[42]   PSYCHOTROPIC MEDICATIONS AND PRIAPISM [J].
FABIAN, JL .
AMERICAN JOURNAL OF PSYCHIATRY, 1993, 150 (02) :349-350
[43]   Psychiatric illness presenting with a sexual complaint and management by psychotropic medications: A case report [J].
Krychman, Michael ;
Carter, Jeanne ;
Amsterdam, Alison .
JOURNAL OF SEXUAL MEDICINE, 2008, 5 (01) :223-226
[44]   SEXUAL DYSFUNCTION AND ANTIDEPRESSANT MEDICATIONS IN MALE DEPRESSED PATIENTS [J].
Karaiskos, D. ;
Tzavellas, E. ;
Elias, I. ;
Liappas, I. ;
Liappas, A. ;
Paparrigopoulos, T. .
EUROPEAN PSYCHIATRY, 2014, 29
[45]   MULTIPLE-SCLEROSIS - SEXUAL DYSFUNCTION AND ITS RESPONSE TO MEDICATIONS [J].
MATTSON, D ;
PETRIE, M ;
SRIVASTAVA, DK ;
MCDERMOTT, M .
ARCHIVES OF NEUROLOGY, 1995, 52 (09) :862-868
[46]   REVIEW OF PSYCHOTROPIC MEDICATIONS AND GLAUCOMAS [J].
REID, WH ;
BLOUIN, P ;
SCHERMER, M .
INTERNATIONAL PHARMACOPSYCHIATRY, 1976, 11 (03) :163-174
[47]   Assessment of addiction to psychotropic medications [J].
Bischof, G. ;
John, U. ;
Rumpf, H. -J. .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2009, 134 (47) :2397-2398
[48]   PSYCHOTROPIC MEDICATIONS AND TRAFFIC SAFETY [J].
LINNOILA, M .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1992, 12 (06) :384-385
[49]   Utilisation of psychotropic medications - Reply [J].
Thiels, C .
BRITISH JOURNAL OF PSYCHIATRY, 2005, 186 :167-168
[50]   PSYCHOTROPIC MEDICATIONS - NURSING IMPLICATIONS [J].
GRIMM, PM .
NURSING CLINICS OF NORTH AMERICA, 1986, 21 (03) :397-411