Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases

被引：281

作者：

Choi, Sangyong ^{[1
]}

Liu, Xian ^{[1
]}

Pan, Zui ^{[1
]}

机构：

[1] Univ Texas Arlington, Coll Nursing & Hlth Innovat, Arlington, TX 76019 USA

来源：

ACTA PHARMACOLOGICA SINICA | 2018年 / 39卷 / 07期

关键词：

zinc homeostasis; zinc transporter (ZnT); Zrt; Irt-like protein (ZIP); metallothionein (MT); cardiovascular diseases; atherosclerosis; inflammation; ROS; ACUTE MYOCARDIAL-INFARCTION; TYPE-2; DIABETES-MELLITUS; GENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; PROTEIN-KINASE-C; DIETARY ZINC; TRANSPORTER ZNT8; IN-VIVO; EXTRACELLULAR VESICLES; SUPEROXIDE-DISMUTASE;

D O I：

10.1038/aps.2018.25

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Zinc is an essential nutrient for human health and has anti-oxidative stress and anti-inflammatory functions. The association between zinc deficiency and the development of cardiovascular diseases (CVDs) has been supported by numerous studies. Supplementing zinc can reduce the risk of atherosclerosis and protect against myocardial infarction and ischemia/reperfusion injury. In this review we summarize the evidence in the literature, to consolidate the current knowledge on the dysregulation of zinc homeostasis in CVDs, and to explore the significant roles of the zinc homeostasis-regulatory proteins in cardiac physiology and pathophysiology. Moreover, this review also deliberates on the potential diagnostic and prognostic implications of zinc/zinc homeostasis-associated molecules (ZIP, ZnT, and MTs) in CVDs.

引用

页码：1120 / 1132

页数：13

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