Hematopoietic stem cell transplant as a platform for tumor immunotherapy

被引：0

作者：

Fuchs, EJ ^{[1
]}

Whartenby, KA ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Div Immunol & Hematopoiesis, Baltimore, MD 21231 USA

来源：

CURRENT OPINION IN MOLECULAR THERAPEUTICS | 2004年 / 6卷 / 01期

关键词：

blood or marrow transplant; donor lymphocyte infusion; gene therapy; immunotherapy; tumor vaccine;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Blood or marrow transplantation (BMT) has been utilized as a cancer therapy with varying levels of success. While it has been an important option for many hematological malignancies, it has met with less success in solid tumors. More recently, new combinations of therapies with BMT have been developed to enhance the efficacy of this therapy and to expand the number of target tumors. This review highlights current uses of BMT, rationales for experimental approaches using BMT alone or as a part of a combination therapy, and reviews some of the novel therapies that have been developed in tumor immunotherapy with BMT, in addition to the implications for translation.

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页码：48 / 53

页数：6

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共 53 条

[1] Toxicity and efficacy of defined doses of CD4+ donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant [J].

Alyea, EP ;

Soiffer, RJ ;

Canning, C ;

Neuberg, D ;

Schlossman, R ;

Pickett, C ;

Collins, H ;

Wang, YL ;

Anderson, KC ;

Ritz, J .

BLOOD, 1998, 91 (10) :3671-3680

[2] Immunization of allogeneic bone marrow transplant recipients with tumor cell vaccines enhances graft-versus-tumor activity without exacerbating graft-versus-host disease [J].

Anderson, LD ;

Savary, CA ;

Mullen, CA .

BLOOD, 2000, 95 (07) :2426-2433

[3]

Anderson LD, 1999, CANCER RES, V59, P1525

[4] Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery [J].

Asavaroengchai, W ;

Kotera, Y ;

Mulé, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :931-936

[5] A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma [J].

Attal, M ;

Harousseau, JL ;

Stoppa, AM ;

Sotto, JJ ;

Fuzibet, JG ;

Rossi, JF ;

Casassus, P ;

Maisonneuve, H ;

Facon, T ;

Ifrah, N ;

Payen, C ;

Bataille, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (02) :91-97

[6] Treatment of multiple myeloma [J].

Barlogie, B ;

Shaughnessy, J ;

Tricot, G ;

Jacobson, J ;

Zangari, M ;

Anaissie, E ;

Walker, R ;

Crowley, J .

BLOOD, 2004, 103 (01) :20-32

[7] Adoptive immunotherapy with donor lymphocyte infusions after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning [J].

Bethge, WA ;

Hegenbart, U ;

Stuart, MJ ;

Storer, BE ;

Maris, MB ;

Flowers, MED ;

Maloney, DG ;

Chauncey, T ;

Bruno, B ;

Agura, E ;

Forman, SJ ;

Blume, KG ;

Niederwieser, D ;

Storb, R ;

Sandmaier, BM .

BLOOD, 2004, 103 (03) :790-795

[8] HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia [J].

Bonini, C ;

Ferrari, G ;

Verzeletti, S ;

Servida, P ;

Zappone, E ;

Ruggieri, L ;

Ponzoni, M ;

Rossini, S ;

Mavilio, F ;

Traversari, C ;

Bordignon, C .

SCIENCE, 1997, 276 (5319) :1719-1724

[9]

Borrello I, 2000, BLOOD, V95, P3011

[10] Nonmyeloablative conditioning followed by hematopoietic cell allografting and donor lymphocyte infusions for patients with metastatic renal and breast cancer [J].

Bregni, M ;

Dodero, A ;

Peccatori, J ;

Pescarollo, A ;

Bernardi, M ;

Sassi, I ;

Voena, C ;

Zaniboni, A ;

Bordignon, C ;

Corradini, P .

BLOOD, 2002, 99 (11) :4234-4236

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