Small molecule delivery through nanofibrous scaffolds for musculoskeletal regenerative engineering

被引：37
作者：
Carbone, Erica J. [1 ,2 ,3 ]
Jiang, Tao [1 ,2 ,3 ]
Nelson, Clarke [1 ,2 ,5 ]
Henry, Nicole [1 ]
Lo, Kevin W. -H. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Connecticut, Ctr Hlth, Sch Med, Inst Regenerat Engn, Farmington, CT 06030 USA
[2] Univ Connecticut, Ctr Hlth, Raymond & Beverly Sackler Ctr Biomed Biol Phys &, Sch Med, Farmington, CT 06030 USA
[3] Univ Connecticut, Ctr Hlth, Sch Med, Dept Med,Div Endocrinol, Farmington, CT 06030 USA
[4] Univ Connecticut, Sch Engn, Dept Biomed Engn, Storrs, CT 06268 USA
[5] Univ Connecticut, Ctr Hlth, Sch Med, Dept Orthopaed Surg, Farmington, CT 06030 USA
来源：
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2014年 / 10卷 / 08期
基金：
美国国家科学基金会;
关键词：
Small molecules; Tissue engineering; Nanofibers; Drug delivery; Musculoskeletal disorders; BONE MORPHOGENETIC PROTEINS; STEM-CELLS; CONTROLLED-RELEASE; IN-VITRO; ELECTROSPUN NANOFIBERS; ZOLEDRONIC ACID; MOTOR-NEURONS; GENE DELIVERY; DIFFERENTIATION; ACTIVATION;
D O I：
10.1016/j.nano.2014.05.013
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Musculoskeletal regenerative engineering approach using small bioactive molecules in conjunction with advanced materials has emerged as a highly promising strategy for musculoskeletal repair and regeneration. Advanced biomaterials technologies have revealed nanofiber-based scaffolds for musculoskeletal tissue engineering as vehicles for the controlled delivery of small molecule drugs. This review article highlights recent advances in nanofiber-based delivery of small molecules for musculoskeletal regenerative engineering. The article concludes with perspectives on the challenges and future directions. From the Clinical Editor: In this review, advances in nanofiber-based delivery of small molecules are discussed from the standpoint of their potential role in musculoskeletal regenerative engineering, highlighting both future directions and current challenges. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：1691 / 1699
页数：9
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