Why Does Infection With Some Helminths Cause Cancer?

被引：102

作者：

Brindley, Paul J. ^{[1
,2
]}

Correia da Costa, Jose M. ^{[3
,4
]}

Sripa, Banchob ^{[5
,6
]}

机构：

[1] George Washington Univ, Dept Microbiol Immunol & Trop Med, Sch Med & Hlth Sci, Washington, DC 20037 USA

[2] George Washington Univ, Sch Med & Hlth Sci, Res Ctr Neglected Dis Poverty, Washington, DC 20037 USA

[3] Natl Inst Hlth Dr Ricardo Jorge, Ctr Parasite Biol & Immunol, Rua Alexandre Herculano 321, P-4000055 Porto, Portugal

[4] Univ Porto, Inst Agr & Agroalimentary Sci & Technol ICETA, Ctr Study Anim CECA, Porto, Portugal

[5] Khon Kaen Univ, Fac Med, Trop Dis Res Lab, Dept Pathol, Khon Kaen 40002, Thailand

[6] Khon Kaen Univ, WHO Collaborating Ctr Res & Control Opisthorchias, Fac Med, Khon Kaen 40002, Thailand

来源：

TRENDS IN CANCER | 2015年 / 1卷 / 03期

基金：

美国国家卫生研究院;

关键词：

FLUKE OPISTHORCHIS-VIVERRINI; BILIARY-TRACT CANCER; SCHISTOSOMA-HAEMATOBIUM; CATECHOL-ESTROGENS; WHOLE-GENOME; DNA-ADDUCTS; DISEASE; RISK; HELICOBACTER; MECHANISMS;

D O I：

10.1016/j.trecan.2015.08.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Infections with Opisthorchis viverrini, Clonorchis sinensis, and Schistosoma haematobium are classified as group 1 biological carcinogens: definitive causes of cancer. These worms are metazoan eukaryotes, unlike the other group 1 carcinogens including human papilloma virus, hepatitis C virus, and Helicobacter pylori. By contrast, infections with phylogenetic relatives of these helminths, also trematodes of the phylum Platyhelminthes and major human pathogens, are not carcinogenic. These inconsistencies prompt several questions, including how might these infections cause cancer, and why is infection with only a few helminth species carcinogenic? We present an interpretation of mechanisms contributing to the carcinogenicity of these helminth infections, including roles for metabolites of catechol estrogen and oxysterols of parasite origin as initiators of carcinogenesis.

引用

收藏

页码：174 / 182

页数：9

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