Preparation and inductive heating property of Fe3O4-chitosan composite nanoparticles in an AC magnetic field for localized hyperthermia

被引：109

作者：

Zhao, Dong-Lin ^{[1
]}

Wang, Xiu-Xia ^{[1
]}

Zeng, Xian-Wei ^{[1
]}

Xia, Qi-Sheng ^{[2
]}

Tang, Jin-Tian ^{[3
]}

机构：

[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

[2] China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China

[3] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China

来源：

JOURNAL OF ALLOYS AND COMPOUNDS | 2009年 / 477卷 / 1-2期

关键词：

Nanostructures; Nanofabrications; Scanning and transmission electron microscopy; X-ray diffraction; Magnetic measurements; AQUEOUS-SOLUTION; MFE2O4; M; CHITOSAN; ADSORPTION; IMMOBILIZATION; CRYSTALLINE; PARTICLES; DEXTRAN; FUTURE; CELLS;

D O I：

10.1016/j.jallcom.2008.10.104

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Magnetite (Fe3O4) nanoparticles were prepared by coprecipitation of Fe3+ and Fe2+ with an aqueous NaOH solution. The Fe3O4-chitosan magnetic composite nanoparticles with a core-shell structure with a diameter of 30-50 nm were synthesized by two steps via a suspension cross-linking method. The inductive heating property of Fe3O4-chitosan composite nanoparticles in an alternating current (AC) magnetic field was investigated. The potential of Fe3O4-chitosan composite nanoparticles was evaluated for localized hyperthermia treatment of cancers. The saturation magnetization, M-s, and coercivity, H-c, were 65.53 emu g(-1) and 0 Oe for Fe3O4 nanoparticles and 24.67 emu g(-1) and 21.69 Oe for Fe3O4-chitosan composite nanoparticles, respectively. After exposed in the AC magnetic field for 29 min, the temperatures of physiological saline suspensions containing Fe3O4 nanoparticles or Fe3O4-chitosan composite nanoparticles were 97.5 degrees C and 53.7 degrees C, respectively. The Fe3O4-chitosan composite nanoparticles would be good thermoseeds for localized hyperthermia cancer therapy. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：739 / 743

页数：5

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