Sex differences in integrated neurocardiovascular control of blood pressure following acute intermittent hypercapnic hypoxia

被引:24
作者
Jacob, Dain W. [1 ]
Ott, Elizabeth P. [1 ]
Baker, Sarah E. [2 ]
Scruggs, Zachariah M. [2 ]
Ivie, Clayton L. [1 ]
Harper, Jennifer L. [1 ]
Manrique-Acevedo, Camila M. [3 ,4 ,5 ]
Limberg, Jacqueline K. [1 ,2 ]
机构
[1] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO 65211 USA
[2] Mayo Clin, Dept Anesthesiol, Rochester, MN 55905 USA
[3] Univ Missouri, Dept Med, Columbia, MO USA
[4] Harry S Truman Mem Vet Hosp, Res Serv, Columbia, MO 65201 USA
[5] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO USA
基金
美国国家卫生研究院;
关键词
baroreceptors; baroreflex; hypoxia; intermittent hypoxia; muscle sympathetic nerve activity; sympathetic nervous system; SYMPATHETIC-NERVE ACTIVITY; OBSTRUCTIVE SLEEP-APNEA; CARDIAC-OUTPUT; ARTERIAL-PRESSURE; BAROREFLEX SENSITIVITY; GENDER-DIFFERENCES; SYSTEMIC HYPOXIA; HEART-RATE; HYPERTENSION; HUMANS;
D O I
10.1152/ajpregu.00191.2020
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Repetitive hypoxic apneas, similar to those observed in sleep apnea, result in resetting of the sympathetic baroreflex to higher blood pressures (BP). This baroreflex resetting is associated with hypertension in preclinical models of sleep apnea (intermittent hypoxia, IH); however, the majority of understanding comes from males. There are data to suggest that female rats exposed to IH do not develop high BP. Clinical data further support sex differences in the development of hypertension in sleep apnea, but mechanistic data are lacking. Here we examined sex-related differences in the effect of IH on sympathetic control of BP in humans. We hypothesized that after acute IH we would observe a rise in muscle sympathetic nerve activity (MSNA) and arterial BP in young men (n = 30) that would be absent in young women (n = 19). BP and MSNA were measured during normoxic rest before and after 30 min of IH. Baroreflex sensitivity (modified Oxford) was evaluated before and after IH. A rise in mean BP following IH was observed in men (+2.0 +/- 0.7 mmHg, P = 0.03), whereas no change was observed in women (-2.7 +/- 1.2 mmHg, P = 0.11). The elevation in MSNA following IH was not different between groups (4.7 +/- 1.1 vs. 3.8 +/- 1.2 bursts/min, P = 0.65). Sympathetic baroreflex sensitivity did not change after IH in either group (P > 0.05). Our results support sex-related differences in the effect of IH on neurovascular control of BP and show that any BP-raising effects of IH are absent in young women. These data enhance our understanding of sex-specific mechanisms that may contribute to BP changes in sleep apnea.
引用
收藏
页码:R626 / R636
页数:11
相关论文
共 88 条
[1]   Increased Sympathetic Nerve Activity in COPD is Associated with Morbidity and Mortality [J].
Andreas, Stefan ;
Haarmann, Helge ;
Klarner, Stephan ;
Hasenfuss, Gerd ;
Raupach, Tobias .
LUNG, 2014, 192 (02) :235-241
[2]   Increased muscle sympathetic nerve activity predicts mortality in heart failure patients [J].
Barretto, Antonio C. P. ;
Santos, Amilton C. ;
Munhoz, Robinson ;
Rondon, Maria U. P. B. ;
Franco, Fabio G. ;
Trombetta, Ivani C. ;
Roveda, Fabiana ;
de Matos, Luciana N. J. ;
Braga, Ana M. W. ;
Middlekauff, Holly R. ;
Negrao, Carlos E. .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2009, 135 (03) :302-307
[3]   Pulse contour cardiac output derived from non-invasive arterial pressure in cardiovascular disease [J].
Bogert, L. W. J. ;
Wesseling, K. H. ;
Schraa, O. ;
Van Lieshout, E. J. ;
de Mol, B. A. J. M. ;
van Goudoever, J. ;
Westerhof, B. E. ;
van Lieshout, J. J. .
ANAESTHESIA, 2010, 65 (11) :1119-1125
[4]   Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger [J].
Bogert, LWJ ;
van Lieshout, JJ .
EXPERIMENTAL PHYSIOLOGY, 2005, 90 (04) :437-446
[5]   Quantifying sympathetic neuro-haemodynamic transduction at rest in humans: insights into sex, ageing and blood pressure control [J].
Briant, L. J. B. ;
Burchell, A. E. ;
Ratcliffe, L. E. K. ;
Charkoudian, N. ;
Nightingale, A. K. ;
Paton, J. F. R. ;
Joyner, Michael J. ;
Hart, E. C. .
JOURNAL OF PHYSIOLOGY-LONDON, 2016, 594 (17) :4753-4768
[6]   Sleep Apnea and Hypertension Are There Sex Differences? The Vitoria Sleep Cohort [J].
Cano-Pumarega, Irene ;
Barbe, Ferrn ;
Esteban, Andres ;
Martinez-Alonso, Montserrat ;
Egea, Carlos ;
Durn-Cantolla, Joaquin .
CHEST, 2017, 152 (04) :742-750
[7]  
Casey DP, 1985, J APPL PHYSL 1985, V116, P927
[8]   IMPLICATIONS OF SMALL REDUCTIONS IN DIASTOLIC BLOOD-PRESSURE FOR PRIMARY PREVENTION [J].
COOK, NR ;
COHEN, J ;
HEBERT, PR ;
TAYLOR, JO ;
HENNEKENS, CH .
ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (07) :701-709
[9]   The use of real-time ultrasound in microneurography [J].
Curry, Timothy B. ;
Charkoudian, Nisha .
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2011, 162 (1-2) :89-93
[10]   Periods of intermittent hypoxic apnea can alter chemoreflex control of sympathetic nerve activity in humans [J].
Cutler, MJ ;
Swift, NM ;
Keller, DM ;
Wasmund, WL ;
Burk, JR ;
Smith, ML .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 287 (05) :H2054-H2060