Pathophysiological rat model of vascular dementia: Magnetic resonance spectroscopy, microimaging and behavioral study

被引：7

作者：

Galisova, Andrea ^{[1
]}

Baciak, Ladislav ^{[1
]}

Jozefovicova, Maria ^{[1
]}

Kukurova, Ivica Just ^{[1
,2
]}

Kebis, Anton ^{[3
]}

Ambrusova, Katarina ^{[3
]}

Dubovicky, Michal ^{[4
]}

Csaszarova, Estera ^{[4
]}

Sadlonova, Irina ^{[5
]}

Kronnerwetter, Claudia ^{[2
]}

Berg, Andreas ^{[2
,6
]}

Krssak, Martin ^{[2
,7
]}

Kasparova, Svatava ^{[1
]}

机构：

[1] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Bratislava, Slovakia

[2] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, High Field MR Ctr Excellence, Vienna, Austria

[3] Slovak Med Univ, Bratislava, Slovakia

[4] Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Bratislava, Slovakia

[5] Hameln RDS, Dept Toxicol, Modra, Slovakia

[6] Med Univ Vienna, Ctr Med Phys & Biomed Engn, A-1090 Vienna, Austria

[7] Med Univ Vienna, Dept Internal Med 3, Div Endocrinol & Metab, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

来源：

BRAIN RESEARCH | 2014年 / 1568卷

关键词：

vascular dementia; rat; chronic cerebral hypoperfusion; magnetic resonance spectroscopy; microimaging; CAROTID-ARTERY OCCLUSION; AGE-RELATED-CHANGES; ALZHEIMERS-DISEASE; TRANSGENIC MICE; COGNITIVE IMPAIRMENT; EXPLORATORY-BEHAVIOR; NEURITIC PLAQUES; BLOOD-FLOW; BRAIN; STRESS;

D O I：

10.1016/j.brainres.2014.04.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic cerebral hypoperfusion and aging can be related to vascular dementia manifested by the decline in cognitive abilities and memory impairment. The identification of specific biomarkers of vascular disorder in early stages is important for the development of neuroprotective agents. In the present study, a three-vessel occlusion (3-VO) rat model of vascular dementia in the middle-aged rat brain was used to investigate the effect of global cerebral hypoperfusion. A multimodal study was performed using magnetic resonance spectroscopy, MR-microimaging, histology and behavioral tests. Our measurements showed a signal alteration in T2-weighted MR images, the elevation of T2 relaxation times and histologically proven neural cell death in the hippocampal area, as well as mild changes in concentration of proton and phosphorus metabolites. These changes were accompanied by mild behavioral alterations in the open field and slightly decreased habituation. The analysis of the effects of vascular pathology on cognitive functions and neurodegeneration can contribute to the development of new treatment strategies for early stages of neurodegeneration. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：10 / 20

页数：11

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