The variance for the disequilibrium coefficient in the individual Hardy-Weinberg test

被引：16

作者：

Chen, JJ

Thomson, G

机构：

[1] Univ Calif Berkeley, Sch Publ Hlth, Div Biostat, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

来源：

BIOMETRICS | 1999年 / 55卷 / 04期

关键词：

disequilibrium coefficient; Hardy-Weinberg test; individual test;

D O I：

10.1111/j.0006-341X.1999.01269.x

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It is of interest to detect the deviation from Hardy-Weinberg proportion (HWP) for a particular heterozygote. Hernandez and Weir (1989, Biometrics 45, 53-70) suggested a disequilibrium coefficient approach and proposed a 1-d.f. chi(2) test. This note derives the appropriate variance under the null hypothesis for performing this individual HWP test. Examples of applying the test to human genetic disease data are presented.

引用

页码：1269 / 1272

页数：4

共 11 条

[1]

CROW JF, 1988, GENETICS, V119, P473

[2] TESTING FOR HARDY-WEINBERG EQUILIBRIUM IN SMALL SAMPLES [J].