A rare case of limbic encephalitis with anti leucine-rich glioma inactivated-1 (LGI1) antibodies

被引：0

作者：

Shen, Nannan ^{[1
]}

Ren, Haitao ^{[2
]}

Wu, Jiang ^{[1
]}

Feng, Jiachun ^{[1
]}

Cui, Liying ^{[2
]}

Fang, Shaokuan ^{[1
]}

机构：

[1] Jilin Univ, Teaching Hosp 1, Dept Neurol, Changchun 130023, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurol, Beijing 100730, Peoples R China

来源：

NEUROENDOCRINOLOGY LETTERS | 2014年 / 35卷 / 02期

关键词：

LGI1; limbic encephalitis; VGKC; Caspr2; autoimmune encephalitis; PROTEINS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of limbic encephalitis with LGI1 antibodies and cranial MRI abnormality. A 41-year-old woman who presented with confusional state that had started 1 month ago. Brain magnetic resonance imaging revealed hyperintense signal in right basal ganglia followed by hyperintense signals in left hippocampus and bilateral basal ganglia half a month later. This case expands the spectrum of limbic encephalitis to include LGI1 antibodies and cranial MRI changing process.

引用

页码：95 / 97

页数：3

共 10 条

[1] Potassium channel antibodies in two patients with reversible limbic encephalitis [J].

Buckley, C ;

Oger, J ;

Clover, L ;

Tüzün, E ;

Carpenter, K ;

Jackson, M ;

Vincent, A .

ANNALS OF NEUROLOGY, 2001, 50 (01) :73-78

[2] Update on paraneoplastic neurological syndromes [J].

Didelot, Adrien ;

Honnorat, Jerome .

CURRENT OPINION IN ONCOLOGY, 2009, 21 (06) :566-572

[3] Autoimmune epilepsies [J].

Irani, Sarosh R. ;

Bien, Christian G. ;

Lang, Bethan .

CURRENT OPINION IN NEUROLOGY, 2011, 24 (02) :146-153

[4] Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia [J].

Irani, Sarosh R. ;

Alexander, Sian ;

Waters, Patrick ;

Kleopa, Kleopas A. ;

Pettingill, Philippa ;

Zuliani, Luigi ;

Peles, Elior ;

Buckley, Camilla ;

Lang, Bethan ;

Vincent, Angela .

BRAIN, 2010, 133 :2734-2748

[5] LGI proteins in the nervous system [J].

Kegel, Linde ;

Aunin, Eerik ;

Meijer, Dies ;

Bermingham, John R., Jr. .

ASN NEURO, 2013, 5 (03) :167-181

[6] Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series [J].

Lai, Meizan ;

Huijbers, Maartje G. M. ;

Lancaster, Eric ;

Graus, Francesc ;

Bataller, Luis ;

Balice-Gordon, Rita ;

Cowell, John K. ;

Dalmau, Josep .

LANCET NEUROLOGY, 2010, 9 (08) :776-785

[7] What should you know about limbic encephalitis? [J].

Machado, Sara ;

Pinto, Amelia Nogueira ;

Irani, Sarosh R. .

ARQUIVOS DE NEURO-PSIQUIATRIA, 2012, 70 (10) :817-822

[8] Management of Voltage-Gated Potassium Channel Antibody Disorders [J].

Merchut, Michael P. .

NEUROLOGIC CLINICS, 2010, 28 (04) :941-+

[9] Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody [J].

Thieben, MJ ;

Lennon, VA ;

Boeve, BF ;

Aksamit, AJ ;

Keegan, M ;

Vernino, S .

NEUROLOGY, 2004, 62 (07) :1177-1182

[10] Autoantibodies associated with diseases of the CNS: new developments and future challenges [J].

Vincent, Angela ;

Bien, Christian G. ;

Irani, Sarosh R. ;

Waters, Patrick .

LANCET NEUROLOGY, 2011, 10 (08) :759-772

← 1 →