Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain

被引：51

作者：

Spulber, Stefan ^{[1
]}

Mateos, Laura ^{[2
]}

Oprica, Mircea ^{[1
]}

Cedazo-Minguez, Angel ^{[2
]}

Bartfai, Tamas ^{[3
]}

Winblad, Bengt ^{[2
]}

Schultzberg, Marianne ^{[2
]}

机构：

[1] Karolinska Inst, Sect Neurodegenerat, Dept Neurobiol Care Sci & Soc, SE-14186 Stockholm, Sweden

[2] Karolinska Inst, KI Alzheimers Dis Res Ctr, SE-14186 Stockholm, Sweden

[3] Scripps Res Inst, Harold L Dorris Neurol Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 208卷 / 1-2期

基金：

瑞典研究理事会;

关键词：

Arc; BDNF; Cytokine; Dentate gyrus; Immediate early gene; Interleukin; Synaptic strengthening; IMMEDIATE-EARLY GENE; NF-KAPPA-B; ARC MESSENGER-RNA; RAT DENTATE GYRUS; INTERLEUKIN-1; RECEPTORS; SYNAPTIC-TRANSMISSION; RETROSPLENIAL CORTEX; HIPPOCAMPAL-LESIONS; PROTEIN EXPRESSION; IMMUNE ACTIVATION;

D O I：

10.1016/j.jneuroim.2009.01.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-1 (IL-1) is expressed following LTP induction and is required for long-term memory consolidation. We demonstrate that the long-term, but not short-term memory is impaired in a transgenic mouse strain overexpressing the human soluble interleukin-1 receptor antagonist (hsIL-1ra) in the brain. Overexpression of IL-1ra was found to reduce the basal as well as the novelty-induced upregulation of activity-regulated cytoskeleton-associated protein (Arc) in the dentate gyrus and in the retrosplenial cortex. Together with the finding that blocking IL-1 receptors interferes with the BDNF-ERK1/2 pathway, our data suggest an essential role played by physiological levels of IL-1 in long-term memory consolidation. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：46 / 53

页数：8

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