TGF-beta signalling from cell membrane to nucleus through SMAD proteins

被引：3221
作者：
Heldin, CH [1 ]
Miyazono, K [1 ]
tenDijke, P [1 ]
机构：
[1] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,TOSHIMA KU,TOKYO 170,JAPAN
来源：
NATURE | 1997年 / 390卷 / 6659期
关键词：
D O I：
10.1038/37284
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The recent identification of the SMAD family of signal transducer proteins has unravelled the mechanisms by which transforming growth factor-beta (TGF-beta) signals from the cell membrane to the nucleus. Pathway-restricted SMADs are phosphorylated by specific cell-surface receptors that have serine/threonine kinase activity, then they oligomerize with the common mediator Smad4 and translocate to the nucleus where they direct transcription to effect the cell's response to TGF-beta. Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs.
引用
收藏
页码：465 / 471
页数：7
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