Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Presenting with Slowly Progressive Myelitis and Longitudinally Extensive Spinal Cord Lesions

被引：4

作者：

Kudo, Takuya ^{[1
]}

Kimura, Akio ^{[1
]}

Higashida, Kazuhiro ^{[1
]}

Yamada, Megumi ^{[1
]}

Hayashi, Yuichi ^{[1
]}

Shimohata, Takayoshi ^{[1
]}

机构：

[1] Gifu Univ, Grad Sch Med, Dept Neurol, Gifu, Japan

来源：

INTERNAL MEDICINE | 2020年 / 59卷 / 21期

关键词：

astrocytopathy; autoantibody; glial fibrillary acidic protein (GFAP); longitudinally extensive spinal cord lesion (LESCL); myelitis; neuromyelitis optica spectrum disorders (NMOSDs); EMISSION-TOMOGRAPHY;

D O I：

10.2169/internalmedicine.5074-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 65-year-old man with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) who presented with gait disturbance that he had experienced for approximately half a year. On neurological examination, he displayed spastic paraplegia and autonomic dysfunctions including dysuria and constipation. Spinal cord magnetic resonance imaging showed longitudinally extensive spinal cord lesions (LESCLs) extending from the cervical to the thoracic cords. The patient was negative for anti-myelin oligodendrocyte glycoprotein and anti-aquaporin 4 antibodies. Treatment with corticosteroids and intravenous immunoglobulin resulted in a clinical improvement. It is important to distinguish GFAP-A from slowly progressive myelitis with LESCLs.

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收藏

页码：2777 / 2781

页数：5

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