Pyrrolizines: Promising scaffolds for anticancer drugs

被引：56

作者：

Belal, Amany ^{[1
,2
]}

El-Gendy, Bahaa El-Dien M. ^{[3
]}

机构：

[1] Beni Suef Univ, Dept Med Chem, Fac Pharm, Bani Suwayf 62514, Egypt

[2] Taif Univ, Dept Pharmaceut Chem, Fac Pharm, At Taif 21974, Saudi Arabia

[3] Benha Univ, Dept Chem, Fac Sci, Banha 13518, Egypt

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2014年 / 22卷 / 01期

关键词：

Pyrrolizines; Pyrimido pyrrolizines; Thieno pyrrolizines; Pyrrolo pyrrolizine; Indolo pyrrolizine; Perhydropyrrolizines; Anticancer drugs; SAR; CARBINOLAMINE TUMOR INHIBITORS; MITOMYCIN-C; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; ALKYLATING-AGENTS; CHEMICAL-REACTIVITY; ANTITUBULIN AGENTS; DUAL INHIBITORS; CROSS-LINKING; CANCER CELLS;

D O I：

10.1016/j.bmc.2013.11.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pyrrolizine derivatives constitute a class of heterocyclic compounds which can serve as promising scaffolds for anticancer drugs. The unique antitumor properties of mitomycin C inspired chemists to develop different pyrrolizine systems and assess their potential antitumor activities against a wide variety of cancer types. Here we review the different classes of pyrrolizines that possess anticancer potency, with an emphasis on their structure activity relationships, in an effort to pave the way for further development in this promising area of research. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：46 / 53

页数：8

共 62 条

[1] Novel substituted and fused pyrrolizine derivatives: Synthesis, anti-inflammatory and ulcerogenecity studies [J].