Male sexual function in presymptomatic gene carriers and patients with Huntington's disease

被引：9
作者：
Kolenc, Matej [1 ]
Kobal, Jan [2 ]
Podnar, Simon [3 ]
机构：
[1] Gen Hosp Novo Mesto, Dept Neurol, SI-8000 Novo Mesto, Slovenia
[2] Univ Med Ctr Ljubljana, Div Neurol, Clin Dept Vasc Neurol & Intens Neurol Therapy, Ljubljana, Slovenia
[3] Univ Med Ctr Ljubljana, Div Neurol, Inst Clin Neurophysiol, Ljubljana, Slovenia
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2015年 / 359卷 / 1-2期
关键词：
Erection; Huntington's disease; Male sexual dysfunction; Sexual questionnaire; Deterioration of sexual function; Autonomic dysfunction; Depression; Total functional capacity; MOUSE MODEL; TRACK-HD; DYSFUNCTION; TESTOSTERONE; CONSEQUENCES; PREMANIFEST; PROGRESSION; PREDICTORS; DEPRESSION; SYMPTOMS;
D O I：
10.1016/j.jns.2015.11.015
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Aims: To report sexual dysfunction in a systematically studied cohort of men with Huntington's disease (HD), and compare them with control men of a similar age. Methods: In men with HD and asymptomatic HD gene carriers, the male sexual dysfunction questionnaire (International Index of Erectile Function-IIEF, covering erectile and orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction), neurologic assessment using the Unified Huntington's Disease Rating Scale (UHDRS) and the Total Functional Capacity (TFC) Score were utilized. Results: Responses were obtained from 23 HD patients and 2 HD gene carriers. HD patients reported more problems with erection, intercourse satisfaction and overall satisfaction (p<0.05) compared to 41 controls. HD patients generally reported reduced sexual desire and performance. Sexual dysfunction progressed in parallel with patients' decline in motor (UHDRS) and TFC, but was not related to patients' age and duration of disease. Conclusions: Our study demonstrated a significant impact of HD on male sexual function that progressed in parallel with motor and total patient (TFC) dysfunction. Physicians helping HD patients should also consider this largely neglected aspect of the disease. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：312 / 317
页数：6
相关论文
共 44 条
[1]   Psychological consequences and predictors of adverse events in the first 5 years after predictive testing for Huntington's disease [J].
Almqvist, EW ;
Brinkman, RR ;
Wiggins, S ;
Hayden, MR .
CLINICAL GENETICS, 2003, 64 (04) :300-309
[2]   Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus [J].
Argiolas, A ;
Melis, MR .
PROGRESS IN NEUROBIOLOGY, 2005, 76 (01) :1-21
[3]   'All the burden on all the carers': exploring quality of life with family caregivers of Huntington's disease patients [J].
Aubeeluck, Aimee Victoria ;
Buchanan, Heather ;
Stupple, Edward J. N. .
QUALITY OF LIFE RESEARCH, 2012, 21 (08) :1425-1435
[4]   Autonomic symptoms in patients and pre-manifest mutation carriers of Huntington's disease [J].
Aziz, N. A. ;
Anguelova, G. V. ;
Marinus, J. ;
van Dijk, J. G. ;
Roos, R. A. C. .
EUROPEAN JOURNAL OF NEUROLOGY, 2010, 17 (08) :1068-1074
[5]   Comparison of Beck Depression Inventories-IA and -II in psychiatric outpatients [J].
Beck, AT ;
Steer, RA ;
Ball, R ;
Ranieri, WF .
JOURNAL OF PERSONALITY ASSESSMENT, 1996, 67 (03) :588-597
[6]   Antidepressants and Sexual Dysfunction: Mechanisms and Clinical Implications [J].
Clayton, Anita H. ;
Croft, Harry A. ;
Handiwala, Lata .
POSTGRADUATE MEDICINE, 2014, 126 (02) :91-99
[7]  
Craufurd D, 2001, NEUROPSY NEUROPSY BE, V14, P219
[8]   The effects of olanzapine, risperidone, and haloperidol on plasma prolactin levels in patients with schizophrenia [J].
David, SR ;
Taylor, CC ;
Kinon, BJ ;
Breier, A .
CLINICAL THERAPEUTICS, 2000, 22 (09) :1085-1096
[9]   SOCIO-PSYCHIATRIC CONSEQUENCES OF HUNTINGTONS DISEASE [J].
DEWHURST, K ;
OLIVER, JE ;
MCKNIGHT, AL .
BRITISH JOURNAL OF PSYCHIATRY, 1970, 116 (532) :255-&
[10]   Dopamine, the medial preoptic area, and male sexual behavior [J].
Dominguez, JM ;
Hull, EM .
PHYSIOLOGY & BEHAVIOR, 2005, 86 (03) :356-368
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