An efficient and convenient synthesis of pentasubstituted pyrroles from alkyl acetoacetates, dialkyl acetylenedicarboxylates, and amines

被引：13

作者：

Mehrabi, Hossein ^{[1
]}

Anary-Abbasinejad, Mohammad ^{[1
]}

Mirhashemi, Fatemeh ^{[1
]}

机构：

[1] Vali E Asr Univ Rafsanjan, Dept Chem, Rafsanjan 77176, Iran

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 31期

关键词：

Pentasubstituted pyrroles; Alkyl acetoacetates; Dialkyl acetylenedicarboxylates; Amines; TETRA-SUBSTITUTED PYRROLES; GRAM-POSITIVE BACTERIA; ONE-POT SYNTHESIS; 4-COMPONENT REACTION; DIMETHYL ACETYLENEDICARBOXYLATE; UNEXPECTED FORMATION; 3-COMPONENT REACTION; ENAMINO ESTERS; DERIVATIVES; CATALYST;

D O I：

10.1016/j.tetlet.2014.06.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient synthesis of pentasubstituted pyrroles has been developed using a one-pot, two-step reaction. The synthesis of a series of 4-hydroxypenta-1,3-diene-tricarboxylates from alkyl acetoacetates and dialkyl acetylenedicarboxylates in the presence of K2CO3, followed by cyclization with amines, gave the corresponding pyrroles in excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4310 / 4314

页数：5

共 44 条

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