Efficient and practical synthesis of Mannich bases related to gramine mediated by zinc chloride

被引：27

作者：

Dai, Hong-Guang ^{[1
]}

Li, Ji-Tai ^{[1
]}

Li, Tong-Shuang ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Analyt Sci & Technol Hebei Prov, Baoding 071002, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 13期

关键词：

gramine; Mannich reaction; synthesis; zinc chloride;

D O I：

10.1080/00397910600602503

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and practical procedure for the Mannich reaction of secondary amine, formaldehyde, and indole or N-methylindole employing zinc chloride is presented. A series of gramine derivatives were obtained in 58-98% yields at room temperature in EtOH by using this method.

引用

页码：1829 / 1835

页数：7

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[2]

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Geng LJ, 2002, CHINESE J ORG CHEM, V22, P1047

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