Periostin in Eye Diseases

被引：5

作者：

Yoshida, Shigeo ^{[1
]}

Umeno, Yumi ^{[1
]}

Haruta, Masatoshi ^{[1
]}

机构：

[1] Kurume Univ, Sch Med, Dept Ophthalmol, Kurume, Fukuoka, Japan

来源：

PERIOSTIN | 2019年 / 1132卷

关键词：

Vitreoretinal disease; Genome-wide gene expression profiling; Proliferative diabetic retinopathy; Proliferative vitreoretinopathy; Age-related macular degeneration; Fibrovascular membranes; Epiretinal membranes; Neovascularization; Fibrosis; Retina; Choroid; Cornea; Conjunctiva; Pterygia; Glaucoma; Corneal dystrophy; Atopic keratoconjunctivitis; IL-4; IL-13; Serum; Tear; Mouse model of oxygen-induced retinal neovascularization; Mouse model of laser-induced choroidal neovascularization; Single-stranded RNA interference; PROLIFERATIVE DIABETIC-RETINOPATHY; PIGMENT EPITHELIAL-CELLS; TOLL-LIKE RECEPTOR-3; FIBROVASCULAR MEMBRANES; MOUSE MODEL; RNA INTERFERENCE; ANGIOGENESIS SUPPRESSION; MATRICELLULAR PROTEINS; MACROPHAGE PLASTICITY; EPIRETINAL MEMBRANES;

D O I：

10.1007/978-981-13-6657-4_12

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transparency of the eye can be disturbed by several eye diseases. It has recently been reported that periostin plays pivotal roles in the pathogenesis of several eye disease, such as diabetic retinopathy (DR), age-related macular degeneration (AMD), glaucoma, pterygia, corneal dystrophy, and chronic ocular allergic diseases. In these diseases, formation of fibro (vascular) tissue plays an important role. Gene expression profiling of human retinal fibro (vascular) membrane revealed significant up-regulation of periostin. The expression of periostin after environmental perturbations, including IL-4 and/or IL-13 induction, can alter normal physiological interactions among fibroblasts, macrophages and ECM protein in the eye. Modulating the expression of periostin by low-molecular weight compounds, antibodies or RNAi directed against the molecule could be a novel therapeutic strategy for inhibiting the progression of those periostin-involved eye diseases.

引用

页码：113 / 124

页数：12