Ground-State Elevation Approach To Suppress Side Reactions in Gold-Sensing Systems Based on Alkyne Activation

被引：50

作者：

Seo, Hyewon ^{[1
,2
]}

Jun, Mi Eun ^{[1
,2
]}

Ranganathan, Koteeswari ^{[1
,2
]}

Lee, Kyung-Ha ^{[3
]}

Kim, Kyong-Tai ^{[3
]}

Lim, Woocherl ^{[1
,2
]}

Rhee, Young Min ^{[1
,2
]}

Ahn, Kyo Han ^{[1
,2
]}

机构：

[1] POSTECH, Dept Chem, Pohang 790784, South Korea

[2] POSTECH, Ctr Electrobehav Adv Mol Syst, Pohang 790784, South Korea

[3] POSTECH, Dept Life Sci, Pohang 790784, South Korea

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

SELECTIVE FLUORESCENT-PROBE; AQUEOUS-MEDIA; RATIOMETRIC DETECTION; IONS; AU3+; CATALYSIS; NANOPARTICLES; CYCLIZATION; SENSOR; HG2+;

D O I：

10.1021/ol5001389

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach to suppress the side reactions observed in the reaction-based gold-sensing systems based on the alkyne activation is disclosed. By elevating steric strain around the reaction site, the gold ion promoted ring-opening process in rhodamine-lactam probes is significantly accelerated, which also leads to suppression of those possible side reactions. As a result, the probes show very high sensitivity in addition to excellent selectivity toward gold species. Furthermore, bioimaging of gold species in live cells was demonstrated with a FRET version.

引用

页码：1374 / 1377

页数：4

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