Follicular Helper T Cells: Lineage and Location

被引：472

作者：

Fazilleau, Nicolas ^{[1
]}

Mark, Linda ^{[1
]}

McHeyzer-Williams, Louise J. ^{[1
]}

McHeyzer-Williams, Michael G. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

来源：

IMMUNITY | 2009年 / 30卷 / 03期

基金：

美国国家卫生研究院;

关键词：

TRANSCRIPTIONAL REPRESSOR BLIMP-1; INDEPENDENT GERMINAL-CENTERS; ANTIGEN-DRIVEN SELECTION; CXC CHEMOKINE RECEPTOR-5; PRIMARY IMMUNE-RESPONSE; IN-VIVO REVEALS; B-CELLS; TGF-BETA; LYMPHOCYTE INTERACTIONS; COSTIMULATORY RECEPTOR;

D O I：

10.1016/j.immuni.2009.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-wise development of antigen-specific B cell immunity in vivo. Deployment of CXCR5(+) Tfh cells to B cell zones of lymphoid tissues and stable cognate interactions with B cells are central to the delivery of antigen-specific Tfh cell function. Here, we review recent advances that have helped to unravel distinctive elements of developmental programming for Tfh cells and unique effector Tfh cell functions focused on antigen-primed B cells. Understanding the regulatory functions of Tfh cells in the germinal center and the subsequent regulation of memory B cell responses to antigen recall represent the frontiers of this research area with the potential to alter fundamentally the design of future vaccines.

引用

页码：324 / 335

页数：12

共 121 条

[1] Germinal-center organization and cellular dynamics [J].

Allen, Christopher D. C. ;

Okada, Takaharu ;

Cyster, Jason G. .

IMMUNITY, 2007, 27 (02) :190-202

[2] Imaging of germinal center selection events during affinity maturation [J].

Allen, Christopher D. C. ;

Okada, Takaharu ;

Tang, H. Lucy ;

Cyster, Jason G. .

SCIENCE, 2007, 315 (5811) :528-531

[3] Phenotypic analysis of antigen-specific T lymphocytes [J].

Altman, JD ;

Moss, PAH ;

Goulder, PJR ;

Barouch, DH ;

McHeyzerWilliams, MG ;

Bell, JI ;

McMichael, AJ ;

Davis, MM .

SCIENCE, 1996, 274 (5284) :94-96

[4] A chemokine-driven positive feedback loop organizes lymphoid follicles [J].

Ansel, KM ;

Ngo, VN ;

Hyman, PL ;

Luther, SA ;

Förster, R ;

Sedgwick, JD ;

Browning, JL ;

Lipp, M ;

Cyster, JG .

NATURE, 2000, 406 (6793) :309-314

[5] In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines [J].

Ansel, KM ;

McHeyzer-Williams, LJ ;

Ngo, VN ;

McHeyzer-Williams, MG ;

Cyster, JG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (08) :1123-1134

[6] MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A MURINE LIGAND FOR CD40 [J].

ARMITAGE, RJ ;

FANSLOW, WC ;

STROCKBINE, L ;

SATO, TA ;

CLIFFORD, KN ;

MACDUFF, BM ;

ANDERSON, DM ;

GIMPEL, SD ;

DAVISSMITH, T ;

MALISZEWSKI, CR ;

CLARK, EA ;

SMITH, CA ;

GRABSTEIN, KH ;

COSMAN, D ;

SPRIGGS, MK .

NATURE, 1992, 357 (6373) :80-82

[7] The germinal center response is impaired in the absence of T cell-expressed CXCR5 [J].

Arnold, Carrie N. ;

Campbell, Daniel J. ;

Lipp, Martin ;

Butcher, Eugene C. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (01) :100-109

[8] The who, how and where of antigen presentation to B cells [J].

Batista, Facundo D. ;

Harwood, Naomi E. .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (01) :15-27

[9] The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells [J].

Bauquet, Aurelie T. ;

Jin, Hulin ;

Paterson, Alison M. ;

Mitsdoerffer, Meike ;

Ho, I-Cheng ;

Sharpe, Arlene H. ;

Kuchroo, Vijay K. .

NATURE IMMUNOLOGY, 2009, 10 (02) :167-175

[10] Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].

Bettelli, E ;

Carrier, YJ ;

Gao, WD ;

Korn, T ;

Strom, TB ;

Oukka, M ;

Weiner, HL ;

Kuchroo, VK .

NATURE, 2006, 441 (7090) :235-238

← 1 2 3 4 5 6 7 8 9 10 →