A magnetic nanogel based on O-carboxymethylchitosan for antitumor drug delivery: synthesis, characterization and in vitro drug release

被引：40

作者：

Demarchi, Carla Albetina ^{[1
]}

Debrassi, Aline ^{[1
]}

Buzzi, Fatima de Campos ^{[1
]}

Correa, Rogerio ^{[1
]}

Cechinel Filho, Valdir ^{[1
]}

Rodrigues, Clovis Antonio ^{[1
]}

Nedelko, Nataliya ^{[2
]}

Demchenko, Pavlo ^{[2
]}

Slawska-Waniewska, Anna ^{[2
]}

Dluzewski, Piotr ^{[2
]}

Greneche, Jean-Marc ^{[3
]}

机构：

[1] Univ Vale Itajai UNIVALI, Nucleo Invest Quim Farmaceut NIQFAR, BR-88302202 Itajai, Santa Catarina, Brazil

[2] Polish Acad Sci, Inst Phys, PL-02668 Warsaw, Poland

[3] Univ Maine, UMR CNRS 6087, Lab Phys Etat Condense, F-72085 Le Mans, France

来源：

SOFT MATTER | 2014年 / 10卷 / 19期

关键词：

NANOPARTICLES; CHITOSAN; NANOMATERIALS; PACLITAXEL; HYDROGELS; CARRIERS; FE3O4;

D O I：

10.1039/c3sm53157k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This paper studied the synthesis, characterization and use of the magnetic chitosan nanogel for carrying meleimidic compounds. The hydrogel polymer was prepared using O-carboxymethylchitosan, which was crosslinked with epichlorohydrin for subsequent incorporation of iron oxide magnetic nanoparticles. The characterization revealed that the magnetic material comprises about 10% of the hydrogel. This material is comprised of magnetite and maghemite and exhibits ferro-ferrimagnetic behavior. The average particle size is 4.2 nm. There was high incorporation efficiency of maleimides in the magnetic nanogel. The release was of sustained character and there was a greater release when an external magnetic field was applied. The mathematical model that best explained the process of drug release by the magnetic hydrogel was that of Peppas-Sahlin. The magnetic nanogel proved to be an excellent candidate for use in drug-delivery systems.

引用

页码：3441 / 3450

页数：10

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