Piecemeal necrosis of the liver revisited a review

被引：4
作者：
French, S. W. [1 ]
Enbom, E. T. [1 ]
机构：
[1] Harbor UCLA Med Ctr, Dept Pathol, Torrance, CA 90509 USA
来源：
EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2014年 / 96卷 / 03期
关键词：
Immunologic synapse; Autoimmunity; Necrosis; CHRONIC HEPATITIS;
D O I：
10.1016/j.yexmp.2014.03.009
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Piecemeal necrosis of the liver is thought to lead to liver cell necrosis. However the process does not lead to necrosis but rather lead to gradual progressive piecemeal removal of liver cell cytoplasm by T lymphocytes which are sensitized to antigens presented on the liver cell surface to form the immunologic synapse. The cytoplasm is taken up by the T cell and digested by the lysosome in the lymphocyte. By this mechanism the liver cell gradually disappears like the Cheshire cat in Alice in Wonderland. (C) 2014 Published by Elsevier Inc.
引用
收藏
页码：307 / 309
页数：3
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