Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain

被引:122
作者
Dassati, Sarah [1 ]
Waldner, Andreas [1 ]
Schweigreiter, Ruediger [2 ]
机构
[1] Private Hosp Villa Melitta, Dept Neurol Rehabil, Bolzano, Italy
[2] Med Univ Innsbruck, Bioctr, Div Neurobiochem, A-6020 Innsbruck, Austria
基金
奥地利科学基金会;
关键词
Aging; Alzheimer's disease; Apolipoprotein; Inflammation; Lipid peroxidation; Lipocalin; Neurodegeneration; Oxidative stress; Reactive oxygen species; Schizophrenia; Stress response; Stroke; POLYUNSATURATED FATTY-ACIDS; ALZHEIMERS-DISEASE BRAIN; HUMAN CEREBROSPINAL-FLUID; MESSENGER-RNA EXPRESSION; OXIDATIVE STRESS; PSYCHIATRIC-DISORDERS; LIPID-PEROXIDATION; NEURODEGENERATIVE DISEASES; ARACHIDONIC-ACID; LIFE-SPAN;
D O I
10.1016/j.neurobiolaging.2014.01.148
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Apolipoprotein D (ApoD) is an ancient member of the lipocalin family with a high degree of sequence conservation from insects to mammals. It is not structurally related to other major apolipoproteins and has been known as a small, soluble carrier protein of lipophilic molecules that is mostly expressed in neurons and glial cells within the central and peripheral nervous system. Recent data indicate that ApoD not only supplies cells with lipophilic molecules, but also controls the fate of these ligands by modulating their stability and oxidation status. Of particular interest is the binding of ApoD to arachidonic acid and its derivatives, which play a central role in healthy brain function. ApoD has been shown to act as a catalyst in the reduction of peroxidized eicosanoids and to attenuate lipid peroxidation in the brain. Manipulating its expression level in fruit flies and mice has demonstrated that ApoD has a favorable effect on both stress resistance and life span. The APOD gene is the gene that is upregulated the most in the aging human brain. Furthermore, ApoD levels in the nervous system are elevated in a large number of neurologic disorders including Alzheimer's disease, schizophrenia, and stroke. There is increasing evidence for a prominent neuroprotective role of ApoD because of its antioxidant and anti- inflammatory activity. ApoD emerges as an evolutionarily conserved anti-stress protein that is induced by oxidative stress and inflammation and may prove to be an effective therapeutic agent against a variety of neuropathologies, and even against aging. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:1632 / 1642
页数:11
相关论文
共 155 条
[1]   A complex secretory program orchestrated by the inflammasome controls paracrine senescence [J].
Acosta, Juan Carlos ;
Banito, Ana ;
Wuestefeld, Torsten ;
Georgilis, Athena ;
Janich, Peggy ;
Morton, Jennifer P. ;
Athineos, Dimitris ;
Kang, Tae-Won ;
Lasitschka, Felix ;
Andrulis, Mindaugas ;
Pascual, Gloria ;
Morris, Kelly J. ;
Khan, Sadaf ;
Jin, Hong ;
Dharmalingam, Gopuraja ;
Snijders, Ambrosius P. ;
Carroll, Thomas ;
Capper, David ;
Pritchard, Catrin ;
Inman, Gareth J. ;
Longerich, Thomas ;
Sansom, Owen J. ;
Aznar Benitah, Salvador ;
Zender, Lars ;
Gil, Jesus .
NATURE CELL BIOLOGY, 2013, 15 (08) :978-U221
[2]   Inflammation in neurodegenerative diseases [J].
Amor, Sandra ;
Puentes, Fabiola ;
Baker, David ;
van der Valk, Paul .
IMMUNOLOGY, 2010, 129 (02) :154-169
[3]   Oxidative stress in neurodegeneration: cause or consequence? [J].
Andersen, JK .
NATURE MEDICINE, 2004, 10 (07) :S18-S25
[4]   Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid [J].
Ando, Y ;
Brännström, T ;
Uchida, K ;
Nyhlin, N ;
Näsman, B ;
Suhr, O ;
Yamashita, T ;
Olsson, T ;
El Salhy, M ;
Uchino, M ;
Ando, M .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1998, 156 (02) :172-176
[5]   Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients [J].
Arvindakshan, M ;
Sitasawad, S ;
Debsikdar, V ;
Ghate, M ;
Evans, D ;
Horrobin, DF ;
Bennett, C ;
Ranjekar, PK ;
Mahadik, SP .
BIOLOGICAL PSYCHIATRY, 2003, 53 (01) :56-64
[6]   Apolipoprotein D Mediates Autocrine Protection of Astrocytes and Controls Their Reactivity Level, Contributing to the Functional Maintenance of Paraquat-Challenged Dopaminergic Systems [J].
Bajo-Graneras, Raquel ;
Ganfornina, Maria D. ;
Martin-Tejedor, Esperanza ;
Sanchez, Diego .
GLIA, 2011, 59 (10) :1551-1566
[7]   The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. [J].
Nicolas G. Bazan .
Cellular and Molecular Neurobiology, 2006, 26 (4) :901-913
[8]   Altered apolipoprotein D expression in the brain of patients with Alzheimer disease [J].
Belloir, B ;
Kövari, E ;
Surini-Demiri, M ;
Savioz, A .
JOURNAL OF NEUROSCIENCE RESEARCH, 2001, 64 (01) :61-69
[9]   Bioactive lipids in schizophrenia [J].
Berger, Gregor E. ;
Smesny, Stefan ;
Amminger, G. Paul .
INTERNATIONAL REVIEW OF PSYCHIATRY, 2006, 18 (02) :85-98
[10]   Increased Apolipoprotein D Dimer Formation in Alzheimer's Disease Hippocampus is Associated with Lipid Conjugated Diene Levels [J].
Bhatia, Surabhi ;
Jenner, Andrew M. ;
Li, Hongyun ;
Ruberu, Kalani ;
Spiro, Adena S. ;
Shepherd, Claire E. ;
Kril, Jillian J. ;
Kain, Nupur ;
Don, Anthony ;
Garner, Brett .
JOURNAL OF ALZHEIMERS DISEASE, 2013, 35 (03) :475-486