A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders

被引：27
作者：
Ghafouri-Fard, Soudeh [1 ]
Khoshbakht, Tayyebeh [2 ]
Hussen, Bashdar Mahmud [3 ,4 ]
Jamal, Hazha Hadayat [5 ]
Taheri, Mohammad [6 ,7 ]
Hajiesmaeili, Mohammadreza [8 ,9 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Mens Hlth & Reprod Hlth Res Ctr, Tehran, Iran
[3] Hawler Med Univ, Coll Pharm, Dept Pharmacognosy, Erbil, Iraq
[4] Lebanese French Univ, Ctr Res, Strateg Studies, Erbil, Iraq
[5] Salahaddin Univ, Coll Educ, Dept Biol, Erbil, Iraq
[6] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran, Iran
[7] Jena Univ Hosp, Inst Human Genet, Jena, Germany
[8] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, Tehran, Iran
[9] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Dept Anesthesiol, Tehran, Iran
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词：
miR-15b-5p; cancer; biomarker; expression; malignance; ENDOPLASMIC-RETICULUM STRESS; CANCER METASTASIS; APOPTOSIS; INJURY; CELLS; CARCINOMA; TUMORIGENICITY; EXPRESSION; BIOMARKERS; PROTECTS;
D O I：
10.3389/fonc.2022.870996
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
miR-15b-5p is encoded by MIR15B gene. This gene is located on cytogenetic band 3q25.33. This miRNA participates in the pathogenesis of several cancers as well as non-malignant conditions, such as abdominal aortic aneurysm, Alzheimer's and Parkinson's diseases, cerebral ischemia reperfusion injury, coronary artery disease, dexamethasone induced steatosis, diabetic complications and doxorubicin-induced cardiotoxicity. In malignant conditions, both oncogenic and tumor suppressor impacts have been described for miR-15b-5p. Dysregulation of miR-15b-5p in clinical samples has been associated with poor outcome in different kinds of cancers. In this review, we discuss the role of miR-15b-5p in malignant and non-malignant conditions.
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页数：14
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