The synthesis of imidazoline analogs of the Kainoid family

被引：8
作者：
Baumgartner, H [1 ]
OSullivan, AC [1 ]
机构：
[1] CIBA GEIGY AG,CH-4002 BASEL,SWITZERLAND
来源：
TETRAHEDRON | 1997年 / 53卷 / 08期
关键词：
D O I：
10.1016/S0040-4020(97)00005-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In an effort to mimic the anthelmintic and insecticidal activties of kainic 1 and domoic 2 acids with compounds of simpler structure and much easier accessibility, the highly functionalised imidazolines 4, 27, and 28 were prepared. This involved a synthesis of suitably protected beta-aminoglutamic acid derivatives as key intermediates, which were condensed with orthoesters and deprotected to yield the desired compounds. (C) 1997 Elsevier Science Ltd.
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页码：2775 / 2784
页数：10
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