Effect of crystal form on in vivo topical anti-inflammatory activity of corticosteroids

被引：4

作者：

Sohn, YT ^{[1
]}

Kim, SY ^{[1
]}

机构：

[1] Duksung Womens Univ, Coll Pharm, Tobong Gu, Seoul 132714, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2002年 / 25卷 / 04期

关键词：

corticosteroids; crystal form; topical anti-inflammation;

D O I：

10.1007/BF02976618

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of this study was to gain information on the effects of the crystal form of corticosteroids on the topical anti-inflammatory activity. Two different crystal forms, Form A and Form B, of the drugs of prednicarbate, hydrocortisone, betamethasone 17-valerate, prednisolone, and methyl prednisolone were prepared and their topical anti-inflammatory activities were measured using arachidonic acid induced ear edema assay in mice. Two crystal forms of the drugs showed differences in anti-inflammatory activity. Among the drugs examined, Form B of prednicarbate and betamethasone 17-valerate showed significantly more potent anti-inflammatory activities as compared to their Form A.

引用

页码：556 / 559

页数：4

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