Solution-phase parallel synthesis of substituted benzimidazoles

被引：24
|
作者：
Raju, B [1 ]
Nguyen, N [1 ]
Holland, GW [1 ]
机构：
[1] Texas Biotechnol Corp, Dept Chem & Biophys, Houston, TX 77030 USA
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2002年 / 4卷 / 04期
关键词：
D O I：
10.1021/cc000098d
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A solution-phase parallel synthesis of o-phenylenediamines is described. These intermediates were then subsequently converted to benzimidazole scaffolds (three-point diversity) in excellent purities and yields. High-throughput purification of this multistep synthetic sequence was accomplished using polymer-bound scavengers and reagents and liquid-liquid extraction protocols.
引用
收藏
页码：320 / 328
页数：9
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