Microenvironment-Sensitive Fluorescent Dyes for Recognition of Serum Albumin in Urine and Imaging in Living Cells

被引：66

作者：

Zhu, Tao ^{[1
]}

Du, Jianjun ^{[1
]}

Cao, Wenbing ^{[1
]}

Fan, Jiangli ^{[1
]}

Peng, Xiaojun ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China

来源：

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2016年 / 55卷 / 03期

关键词：

INDUCED EMISSION CHARACTERISTICS; RENAL-FUNCTION; SQUARAINE DYE; VISCOSITY; SENSOR; CHROMOPHORE; EXCRETION; DISEASE; BINDING; BIOSENSORS;

D O I：

10.1021/acs.iecr.5b04214

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A series of microenvironment-sensitive fluorescent dyes, SA1-4, have been presented, which can light up human serum albumin (HSA) in aqueous media and solid state with colorful emissions as well as dramatic fluorescence enhancements respectively, based on twisted intramolecular charge transfer and molecular rotor strategy. These microenvironment-sensitive SA1-4 exhibited excellent fluorescent capabilities in the fast, convenient, selective, and sensitive recognition of HSA, especially in the quantitative albumin assay in human urine for assessment of kidney function and diagnosis of renal disease. Moreover, SA1-4/HSA complexes could be applied in fluorescence imaging in living cells.

引用

页码：527 / 533

页数：7

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