Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals

被引：79

作者：

Cai, Zhengxin ^{[1
]}

Anderson, Carolyn J. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15219 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2014年 / 57卷 / 04期

关键词：

PET; copper; 64; chelator; molecular imaging; radiopharmaceutical; BIOLOGICAL EVALUATION; BIFUNCTIONAL CHELATORS; IMAGING AGENTS; PET; CU-64; COMPLEXES; CLICK; CAGE; CONJUGATION; CHEMISTRY;

D O I：

10.1002/jlcr.3165

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of chelating agents for copper radionuclides in positron emission tomography radiopharmaceuticals has been a highly active and important area of study in recent years. The rapid evolution of chelators has resulted in highly specific copper chelators that can be readily conjugated to biomolecules and efficiently radiolabeled to form stable complexes in vivo. Chelators are not only designed for conjugation to monovalent biomolecules but also for incorporation into multivalent targeting ligands such as theranostic nanoparticles. These advancements have strengthened the role of copper radionuclides in the fields of nuclear medicine and molecular imaging. This review emphasizes developments of new copper chelators that have most greatly advanced the field of copper-based radiopharmaceuticals over the past 5years.

引用

页码：224 / 230

页数：7

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