A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro

被引：8
|
作者：
Chen, Ji [1 ]
Li, Guotao [1 ]
Liu, Qihong [1 ]
Liang, Yan [2 ]
Liu, Miaochang [1 ]
Wu, Huayue [1 ]
Gao, Wenxia [1 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China
[2] Qingdao Univ, Sch Pharm, Dept Pharmaceut, Qingdao 266021, Shandong, Peoples R China
来源：
NANOMATERIALS | 2019年 / 9卷 / 06期
基金：
中国国家自然科学基金;
关键词：
prodrug; photocleavable; stimuli-responsive release; methotrexate; chemotherapy; DRUG-DRUG CONJUGATE; TARGETED DELIVERY; THERAPY;
D O I：
10.3390/nano9060860
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.
引用
收藏
页数：10
相关论文
共 50 条
  • [11] Self-assembled nanoparticles based on amphiphilic chitosan derivative and hyaluronic acid for gene delivery
    Liu, Ya
    Kong, Ming
    Cheng, Xiao Jie
    Wang, Qian Qian
    Jiang, Li Ming
    Chen, Xi Guang
    CARBOHYDRATE POLYMERS, 2013, 94 (01) : 309 - 316
  • [12] Folate mediated self-assembled phytosterol-alginate nanoparticles for targeted intracellular anticancer drug delivery
    Wang, Jianting
    Wang, Ming
    Zheng, Mingming
    Guo, Qiong
    Wang, Yafan
    Wang, Heqing
    Xie, Xiangrong
    Huang, Fenghong
    Gong, Renmin
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2015, 129 : 63 - 70
  • [13] Construction and cellular uptake evaluation of redox-responsive docetaxel prodrug self-assembled nanoparticles
    Ren, Guolian
    Chen, Pei
    Tang, Jiaqi
    Wang, Rongrong
    Duan, Shuai
    Wang, Ruili
    Xie, Yin
    Zhang, Shuqiu
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2018, 44 (04) : 598 - 607
  • [14] Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy
    Liu, Demin
    Poon, Christopher
    Lu, Kuangda
    He, Chunbai
    Lin, Wenbin
    NATURE COMMUNICATIONS, 2014, 5
  • [15] Self-Assembled Gemcitabine Prodrug Nanoparticles Show Enhanced Efficacy against Patient-Derived Pancreatic Ductal Adenocarcinoma
    Wu, Liming
    Zhang, Fu
    Chen, Xiaona
    Wan, Jianqin
    Wang, Yuchen
    Li, Tongyu
    Wang, Hangxiang
    ACS APPLIED MATERIALS & INTERFACES, 2020, 12 (03) : 3327 - 3340
  • [16] Intracellularly Degradable, Self-Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy
    Lv, Li
    Guo, Yuan
    Shen, Yuanyuan
    Liu, Jieying
    Zhang, Wenjun
    Zhou, Dejian
    Guo, Shengrong
    ADVANCED HEALTHCARE MATERIALS, 2015, 4 (10) : 1496 - 1501
  • [17] Prodrug-based self-assembled nanoparticles formed by 3′,5′-dioleoyl floxuridine for cancer chemotherapy
    Xu, Hui
    Xiao, Yue
    Tang, Jinlu
    Liu, Dongfang
    Shi, Xinxin
    Aryee, Aaron Albert
    Meng, Hongmin
    Qu, Lingbo
    Li, Zhaohui
    NEW JOURNAL OF CHEMISTRY, 2021, 45 (18) : 8306 - 8313
  • [18] Enhanced Antiglioma Efficacy of Ultrahigh Loading Capacity Paclitaxel Prodrug Conjugate Self-Assembled Targeted Nanoparticles
    Jiang, Yan
    Wang, Xiuzhen
    Liu, Xin
    Lv, Wei
    Zhang, Hongjuan
    Zhang, Mingwan
    Li, Xinrui
    Xin, Hongliang
    Xu, Qunwei
    ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (01) : 211 - 217
  • [19] Docetaxel prodrug self-assembled nanosystem: Synthesis, formulation and cytotoxicity
    Jing, Fanbo
    Guo, Qie
    Xu, Wen
    Qu, Haijun
    Sui, Zhongguo
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (04) : 826 - 830
  • [20] Pharmacokinetics and antimalarial activities of reduction-responsive releasing dihydroartemisinin prodrug self-assembled nanoparticles in rodents
    Wang, Rongrong
    Ren, Guolian
    Chai, Liqing
    Guo, Wenju
    Li, Yujie
    Wang, Ruili
    Zhao, Yongdan
    Zhang, Shuqiu
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 63
12345