A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro

被引：8
|
作者：
Chen, Ji [1 ]
Li, Guotao [1 ]
Liu, Qihong [1 ]
Liang, Yan [2 ]
Liu, Miaochang [1 ]
Wu, Huayue [1 ]
Gao, Wenxia [1 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China
[2] Qingdao Univ, Sch Pharm, Dept Pharmaceut, Qingdao 266021, Shandong, Peoples R China
来源：
NANOMATERIALS | 2019年 / 9卷 / 06期
基金：
中国国家自然科学基金;
关键词：
prodrug; photocleavable; stimuli-responsive release; methotrexate; chemotherapy; DRUG-DRUG CONJUGATE; TARGETED DELIVERY; THERAPY;
D O I：
10.3390/nano9060860
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.
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页数：10
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