ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer

被引：180
作者：
D'Angelo, Stefania [1 ]
Motti, Maria Letizia [1 ]
Meccariello, Rosaria [1 ]
机构：
[1] Univ Napoli Parthenope, Dipartimento Sci Motorie & Benessere, Via Medina 40, I-80133 Naples, Italy
来源：
NUTRIENTS | 2020年 / 12卷 / 09期
关键词：
obesity; omega-3PUFAs; omega-6PUFAs; endocannabinoids; CRC; fatty acids; ADIPOSE-TISSUE INFLAMMATION; M2 MACROPHAGE POLARIZATION; LONG-CHAIN OMEGA-3; STEM-LIKE CELLS; COLORECTAL-CANCER; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; N-3; PUFAS; CARDIOVASCULAR-DISEASE; CANNABINOID RECEPTOR;
D O I：
10.3390/nu12092751
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Recently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (omega-3PUFAs), including alpha-linolenic acid, docosapentaenoic acid, and eicosapentaenoic acid, are mostly attractive. They are available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. The anti-inflammatory and hypotriglyceridemic effects of these fatty acids are well known, whereas pro-inflammatory properties have been recognized in their dietary counterparts, the omega-6PUFAs. Both omega-3 and omega-6PUFAs contribute to the production of lipid mediators such as endocannabinoids that are notably involved in control of food intake, energy sensing, and food-related disorders. In this review, we present omega-3 and omega-6PUFAs and their derivatives, endocannabinoids; discuss the anti-obesity effects of omega-3PUFAs; their roles in inflammation and colorectal cancer development; and how their action can be co-preventative and co-therapeutic.
引用
收藏
页码：1 / 22
页数：22
相关论文
共 138 条
[81]   Annurca apple polyphenol extract selectively kills MDA-MB-231 cells through ROS generation, sustained JNK activation and cell growth and survival inhibition [J].
Martino, Elisa ;
Vuoso, Daniela C. Ristina ;
D'Angelo, Stefania ;
Mele, Luigi ;
D'Onofrio, Nunzia ;
Porcelli, Marina ;
Cacciapuoti, Giovanna .
SCIENTIFIC REPORTS, 2019, 9 (1)
[82]   Early-onset colorectal cancer in young individuals [J].
Mauri, Gianluca ;
Sartore-Bianchi, Andrea ;
Russo, Antonio-Giampiero ;
Marsoni, Silvia ;
Bardelli, Alberto ;
Siena, Salvatore .
MOLECULAR ONCOLOGY, 2019, 13 (02) :109-131
[83]  
MECCARIELLO R, 2014, INT J ENDOCRINOL, V2014, DOI DOI 10.1155/2014/412354
[84]   Endocannabinoid System in Health and Disease: Current Situation and Future Perspectives [J].
Meccariello, Rosaria .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (10)
[85]   The Epigenetics of the Endocannabinoid System [J].
Meccariello, Rosaria ;
Santoro, Antonietta ;
D'Angelo, Stefania ;
Morrone, Rossella ;
Fasano, Silvia ;
Viggiano, Andrea ;
Pierantoni, Riccardo .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (03)
[86]   Why and How Meet n-3 PUFA Dietary Recommendations? [J].
Molendi-Coste, Olivier ;
Legry, Vanessa ;
Leclercq, Isabelle A. .
GASTROENTEROLOGY RESEARCH AND PRACTICE, 2011, 2011
[87]   MicroRNAs, Cancer and Diet: Facts and New Exciting Perspectives [J].
Mott, Maria L. ;
D'Angelo, Stefania ;
Meccariello, Rosaria .
CURRENT MOLECULAR PHARMACOLOGY, 2018, 11 (02) :90-96
[88]   Anti-Obesity Effect of Carotenoids: Direct Impact on Adipose Tissue and Adipose Tissue-Driven Indirect Effects [J].
Mounien, Lourdes ;
Tourniaire, Franck ;
Landrier, Jean-Francois .
NUTRIENTS, 2019, 11 (07)
[89]   Soy and fish oil intake and mortality in a Japanese community [J].
Nagata, C ;
Takatsuka, N ;
Shimizu, H .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 156 (09) :824-831
[90]   Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-γ-dependent mechanism in mice [J].
Neschen, S ;
Morino, K ;
Rossbacher, JC ;
Pongratz, RL ;
Cline, GW ;
Sono, S ;
Gillum, M ;
Shulman, GI .
DIABETES, 2006, 55 (04) :924-928
45678910111213