ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer

被引：179
作者：
D'Angelo, Stefania [1 ]
Motti, Maria Letizia [1 ]
Meccariello, Rosaria [1 ]
机构：
[1] Univ Napoli Parthenope, Dipartimento Sci Motorie & Benessere, Via Medina 40, I-80133 Naples, Italy
来源：
NUTRIENTS | 2020年 / 12卷 / 09期
关键词：
obesity; omega-3PUFAs; omega-6PUFAs; endocannabinoids; CRC; fatty acids; ADIPOSE-TISSUE INFLAMMATION; M2 MACROPHAGE POLARIZATION; LONG-CHAIN OMEGA-3; STEM-LIKE CELLS; COLORECTAL-CANCER; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; N-3; PUFAS; CARDIOVASCULAR-DISEASE; CANNABINOID RECEPTOR;
D O I：
10.3390/nu12092751
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Recently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (omega-3PUFAs), including alpha-linolenic acid, docosapentaenoic acid, and eicosapentaenoic acid, are mostly attractive. They are available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. The anti-inflammatory and hypotriglyceridemic effects of these fatty acids are well known, whereas pro-inflammatory properties have been recognized in their dietary counterparts, the omega-6PUFAs. Both omega-3 and omega-6PUFAs contribute to the production of lipid mediators such as endocannabinoids that are notably involved in control of food intake, energy sensing, and food-related disorders. In this review, we present omega-3 and omega-6PUFAs and their derivatives, endocannabinoids; discuss the anti-obesity effects of omega-3PUFAs; their roles in inflammation and colorectal cancer development; and how their action can be co-preventative and co-therapeutic.
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页码：1 / 22
页数：22
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